Sporadic cerebral amyloid angiopathy (CAA) is a vasculopathy restricted to the central nervous system, related to the deposition of β-amyloid 1-40/42 fragments in the cortical and subcortical vessels. It is considered a rare clinical entity, but no tool neither for an early nor definite diagnosis is available today in vivo. Recurrent atypical cerebral hemorrhages are considered CAAs main clinical expression, although ischaemic lesions are also frequent. We report our experience of five patients presenting relapsing cerebral ischaemias and/or hemorrhages and meeting the Boston Criteria for possible or probable CAA: four of them had a cerebral ischaemia as first clinical event, three of them had a late diagnosis. Notably, they all showed a typical aspect on T2 * Gradient Echo MRI: this technique should be performed in all elderly patients with a cerebrovascular accident, in order to permit an earlier and more sensitive diagnosis of CAA.
ASJC Scopus subject areas
- Internal Medicine