The diagnostic accuracy of Fibroscan® for cirrhosis is influenced by liver morphometry in HCV patients with a sustained virological response

Roberta D'Ambrosio, Alessio Aghemo, Mirella Fraquelli, Maria Grazia Rumi, Maria Francesca Donato, Valerie Paradis, Pierre Bedossa, Massimo Colombo

Research output: Contribution to journalArticlepeer-review

Abstract

Background & Aims Transient elastography (TE) is a validated non-invasive tool to evaluate hepatic fibrosis in patients with hepatitis C virus (HCV) infection. Whether TE may sense changes of liver fibrosis following therapeutic HCV eradication has never been evaluated. Methods 37 HCV cirrhotics with paired pre- and post-sustained virological response (SVR) liver biopsies (LB) underwent TE at the time of post-SVR LB. Liver fibrosis was staged with the METAVIR scoring system and the area of fibrosis (%) was assessed morphometrically. Results Thirty-three patients had valid TE measurements after 61 (48-104) months from an SVR, and 20 (61%) of them had cirrhosis regression. On post-SVR LB, the median area of fibrosis was 2.3%, being significantly reduced from baseline (p

Original languageEnglish
Pages (from-to)251-256
Number of pages6
JournalJournal of Hepatology
Volume59
Issue number2
DOIs
Publication statusPublished - Aug 2013

Keywords

  • Cirrhosis regression
  • Fibroscan®
  • Hepatitis C virus
  • Morphometry
  • Sustained virological response

ASJC Scopus subject areas

  • Hepatology

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