Abstract
Background & Aims Transient elastography (TE) is a validated non-invasive tool to evaluate hepatic fibrosis in patients with hepatitis C virus (HCV) infection. Whether TE may sense changes of liver fibrosis following therapeutic HCV eradication has never been evaluated. Methods 37 HCV cirrhotics with paired pre- and post-sustained virological response (SVR) liver biopsies (LB) underwent TE at the time of post-SVR LB. Liver fibrosis was staged with the METAVIR scoring system and the area of fibrosis (%) was assessed morphometrically. Results Thirty-three patients had valid TE measurements after 61 (48-104) months from an SVR, and 20 (61%) of them had cirrhosis regression. On post-SVR LB, the median area of fibrosis was 2.3%, being significantly reduced from baseline (p
Original language | English |
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Pages (from-to) | 251-256 |
Number of pages | 6 |
Journal | Journal of Hepatology |
Volume | 59 |
Issue number | 2 |
DOIs | |
Publication status | Published - Aug 2013 |
Keywords
- Cirrhosis regression
- Fibroscan®
- Hepatitis C virus
- Morphometry
- Sustained virological response
ASJC Scopus subject areas
- Hepatology