The diagnostic accuracy of Fibroscan® for cirrhosis is influenced by liver morphometry in HCV patients with a sustained virological response

Roberta D'Ambrosio; Alessio Aghemo; Mirella Fraquelli; Maria Grazia Rumi; Maria Francesca Donato; Valerie Paradis; Pierre Bedossa; Massimo Colombo

doi:10.1016/j.jhep.2013.03.013

The diagnostic accuracy of Fibroscan® for cirrhosis is influenced by liver morphometry in HCV patients with a sustained virological response

Roberta D'Ambrosio, Alessio Aghemo, Mirella Fraquelli, Maria Grazia Rumi, Maria Francesca Donato, Valerie Paradis, Pierre Bedossa, Massimo Colombo

Research output: Contribution to journal › Article › peer-review

Abstract

Background & Aims Transient elastography (TE) is a validated non-invasive tool to evaluate hepatic fibrosis in patients with hepatitis C virus (HCV) infection. Whether TE may sense changes of liver fibrosis following therapeutic HCV eradication has never been evaluated. Methods 37 HCV cirrhotics with paired pre- and post-sustained virological response (SVR) liver biopsies (LB) underwent TE at the time of post-SVR LB. Liver fibrosis was staged with the METAVIR scoring system and the area of fibrosis (%) was assessed morphometrically. Results Thirty-three patients had valid TE measurements after 61 (48-104) months from an SVR, and 20 (61%) of them had cirrhosis regression. On post-SVR LB, the median area of fibrosis was 2.3%, being significantly reduced from baseline (p

Original language	English
Pages (from-to)	251-256
Number of pages	6
Journal	Journal of Hepatology
Volume	59
Issue number	2
DOIs	https://doi.org/10.1016/j.jhep.2013.03.013
Publication status	Published - Aug 2013

Keywords

Cirrhosis regression
Fibroscan®
Hepatitis C virus
Morphometry
Sustained virological response

ASJC Scopus subject areas

Hepatology

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10.1016/j.jhep.2013.03.013

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@article{4b68ba7b5ce74a8594d23f35cb8f7b3a,

title = "The diagnostic accuracy of Fibroscan{\textregistered} for cirrhosis is influenced by liver morphometry in HCV patients with a sustained virological response",

abstract = "Background & Aims Transient elastography (TE) is a validated non-invasive tool to evaluate hepatic fibrosis in patients with hepatitis C virus (HCV) infection. Whether TE may sense changes of liver fibrosis following therapeutic HCV eradication has never been evaluated. Methods 37 HCV cirrhotics with paired pre- and post-sustained virological response (SVR) liver biopsies (LB) underwent TE at the time of post-SVR LB. Liver fibrosis was staged with the METAVIR scoring system and the area of fibrosis (%) was assessed morphometrically. Results Thirty-three patients had valid TE measurements after 61 (48-104) months from an SVR, and 20 (61%) of them had cirrhosis regression. On post-SVR LB, the median area of fibrosis was 2.3%, being significantly reduced from baseline (p ",

keywords = "Cirrhosis regression, Fibroscan{\textregistered}, Hepatitis C virus, Morphometry, Sustained virological response",

author = "Roberta D'Ambrosio and Alessio Aghemo and Mirella Fraquelli and Rumi, {Maria Grazia} and Donato, {Maria Francesca} and Valerie Paradis and Pierre Bedossa and Massimo Colombo",

year = "2013",

month = aug,

doi = "10.1016/j.jhep.2013.03.013",

language = "English",

volume = "59",

pages = "251--256",

journal = "Journal of Hepatology",

issn = "0168-8278",

publisher = "Elsevier B.V.",

number = "2",

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TY - JOUR

T1 - The diagnostic accuracy of Fibroscan® for cirrhosis is influenced by liver morphometry in HCV patients with a sustained virological response

AU - D'Ambrosio, Roberta

AU - Aghemo, Alessio

AU - Fraquelli, Mirella

AU - Rumi, Maria Grazia

AU - Donato, Maria Francesca

AU - Paradis, Valerie

AU - Bedossa, Pierre

AU - Colombo, Massimo

PY - 2013/8

Y1 - 2013/8

N2 - Background & Aims Transient elastography (TE) is a validated non-invasive tool to evaluate hepatic fibrosis in patients with hepatitis C virus (HCV) infection. Whether TE may sense changes of liver fibrosis following therapeutic HCV eradication has never been evaluated. Methods 37 HCV cirrhotics with paired pre- and post-sustained virological response (SVR) liver biopsies (LB) underwent TE at the time of post-SVR LB. Liver fibrosis was staged with the METAVIR scoring system and the area of fibrosis (%) was assessed morphometrically. Results Thirty-three patients had valid TE measurements after 61 (48-104) months from an SVR, and 20 (61%) of them had cirrhosis regression. On post-SVR LB, the median area of fibrosis was 2.3%, being significantly reduced from baseline (p

AB - Background & Aims Transient elastography (TE) is a validated non-invasive tool to evaluate hepatic fibrosis in patients with hepatitis C virus (HCV) infection. Whether TE may sense changes of liver fibrosis following therapeutic HCV eradication has never been evaluated. Methods 37 HCV cirrhotics with paired pre- and post-sustained virological response (SVR) liver biopsies (LB) underwent TE at the time of post-SVR LB. Liver fibrosis was staged with the METAVIR scoring system and the area of fibrosis (%) was assessed morphometrically. Results Thirty-three patients had valid TE measurements after 61 (48-104) months from an SVR, and 20 (61%) of them had cirrhosis regression. On post-SVR LB, the median area of fibrosis was 2.3%, being significantly reduced from baseline (p

KW - Cirrhosis regression

KW - Fibroscan®

KW - Hepatitis C virus

KW - Morphometry

KW - Sustained virological response

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The diagnostic accuracy of Fibroscan® for cirrhosis is influenced by liver morphometry in HCV patients with a sustained virological response

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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