The differential effects of PGE on the immune response in normal and immunosuppressed mice

Cartesio Favalli, Peter Leport, Bernard M. Jaffe, M. Gabriella Santoro, Thomas Simmet, Vera Del Gobbo, Enrico Garaci

Research output: Contribution to journalArticle

Abstract

The effect of 16,16-dimethyl-PGE2-methyl ester (di-M-PGE2) on humoral and cellular immunoresponsiveness has been compared in normal mice and in mice immunosuppressed by splenectomy and thymectomy plus antithymocyte serum (ATS). Splenectomy resulted in immunosuppression manifested by augmentation of B-16 melanoma growth; this stimulatory effect was reversed by di-M-PGE2. In animals immunosuppressed by thymectomy plus ATS, di-M-PGE2 augmented the humoral and cellular immune responses; this was manifested by slowing of the growth of B-16 melanoma and by stimulating the number of plaque-forming cells, hemagglutinin titers, and delayed-hypersensitivity reactions to sheep erythrocytes. In contrast, in normal (nonthymectomized) mice, di-M-PGE2 was mildly immunosuppressive. Finally, adriamycin-immunosuppressed normal mice and this suppression were reversed by the addition of di-M-PGE2 to the treatment regimen.

Original languageEnglish
Pages (from-to)351-359
Number of pages9
JournalCellular Immunology
Volume72
Issue number2
DOIs
Publication statusPublished - Sep 15 1982

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

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