The difficulty in confirming clinical diagnosis of myasthenia gravis in a seronegative patient: A possible neurophysiological approach

P. Caliandro, A. Evoli, E. Stålberg, G. Granata, P. Tonali, L. Padua

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In seronegative myasthenia gravis repetitive nerve stimulation and single-fibre EMG have a crucial diagnostic value but they may be negative, particularly in repetitive nerve stimulation studies. We report the case of a 43-year-old patient with generalized seronegative myasthenia gravis with negative 3 Hz repetitive nerve stimulation at Erb's point and voluntary single-fibre EMG in the orbicularis oculi. We also performed 6 and 12 Hz repetitive nerve stimulation at Erb and stimulated single-fibre EMG in the extensor digitorum communis and our findings were pathological. Our data suggest that, for individual patients with an atypical picture characterised by dissociation between a severe clinical pattern and no definite neurophysiological findings on conventional tests, repetitive nerve stimulation with a stimulation rate higher than 3 Hz and/or stimulated single-fibre EMG with an increasing stimulation rate may be helpful.

Original languageEnglish
Pages (from-to)825-827
Number of pages3
JournalNeuromuscular Disorders
Volume19
Issue number12
DOIs
Publication statusPublished - Dec 2009

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Myasthenia Gravis

Keywords

  • Myasthenia gravis
  • Repetitive nerve stimulation
  • Single fibre

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Genetics(clinical)
  • Neurology

Cite this

The difficulty in confirming clinical diagnosis of myasthenia gravis in a seronegative patient : A possible neurophysiological approach. / Caliandro, P.; Evoli, A.; Stålberg, E.; Granata, G.; Tonali, P.; Padua, L.

In: Neuromuscular Disorders, Vol. 19, No. 12, 12.2009, p. 825-827.

Research output: Contribution to journalArticle

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