Valutazione radiografica diretta e computerizzata delle localizzazioni vertebrali nei bambini affetti da leucemia linfatica acuta.

Translated title of the contribution: The direct and computed radiographic assessment of vertebral locations in children with acute lymphatic leukemia

P. Rolla, U. E. Pazzaglia, M. Arico, E. Raiteri, P. Norgia, P. Fiori, G. Beluffi

Research output: Contribution to journalArticlepeer-review

Abstract

The children affected with acute lymphoblastic leukemia (ALL) often exhibit secondary lesions of the spine. The diagnosis of spinal involvement is currently made by means of conventional radiography in postero-anterior and lateral views. The osteolytic lesions of the vertebral body present with collapse of the vertebral plates in a wide range of severity. Body evaluation is usually made by comparison with the adjacent vertebrae. Since leukemia is a systemic disease, several vertebrae are possibly involved in each case. In the attempt to develop a more sensitive method, which is less dependent on observers' evaluation, a quantitative and comparative analysis of vertebral bodies was performed. The radiographs in lateral view of the dorsal and lumbar spine of 14 children with ALL were analyzed: previous radiological reports suggested the lesion of one or more vertebral bodies. The area of each vertebral body was measured and digitalized by means of a backlighted graphic table and of a software developed to this purpose. The criteria to define the collapse of a vertebral body were the ratio between areas of adjacent vertebral bodies, in conformity to the anatomic and radiographic principle that, in the dorsal and lumbar spine, the body of a normal vertebra is equal to or bigger than that of the upper one. The data obtained by quantitative analysis were compared with conventional radiologic reports. A hundred and fifty-five vertebrae were analyzed by computerized analysis; 17 (10.9%) vertebrae, undetected at conventional analysis, were collapsed. This method allows a more precise diagnosis of collapsed vertebral lesions; its accuracy can be improved with further development of digital technology.

Translated title of the contributionThe direct and computed radiographic assessment of vertebral locations in children with acute lymphatic leukemia
Original languageItalian
Pages (from-to)414-418
Number of pages5
JournalRadiologia Medica
Volume83
Issue number4
Publication statusPublished - Apr 1992

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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