Abstract
The placental growth factor (PlGF) is an angiogenic protein belonging to the vascular endothelial growth factor (VEGF) family, which was discovered in 1991 by an Italian scientist, Maria Graziella Persico. Dr Persico cloned and purified PlGF and determined its structure by crystallography resolution. Furthermore, she identified VEGF receptor-1 (VEGFR-1) as the receptor for PlGF, and in collaboration with Dr Peter Carmeliet in Leuven, she generated evidence that loss of PlGF does not affect development, reproduction, or postnatal life. PlGF is expressed primarily in the placenta and is up-regulated in several pathological conditions, although its role is still controversial. Some data in literature reported that PlGF enhances pathological angiogenesis by initiating a cross-talk between VEGFR-1 and VEGFR-2, whereas other studies did not confirm these findings. Regarding the potential therapeutic employment of PlGF, recent evidence has shown that an anti-PlGF antibody may act as a potent antiangiogenic agent, and that it has the advantage of minor toxicity when combined with anti-VEGF strategies.
| Original language | English |
|---|---|
| Pages (from-to) | 215-221 |
| Number of pages | 7 |
| Journal | Angiogenesis |
| Volume | 11 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 2008 |
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Keywords
- Angiogenesis
- Antiangiogenesis
- History of medicine
- Placental growth factor
- Vascular endothelial growth factor
ASJC Scopus subject areas
- Cancer Research
- Clinical Biochemistry
- Polymers and Plastics
- Pathology and Forensic Medicine
Cite this
The discovery of the placental growth factor and its role in angiogenesis : A historical review. / Ribatti, Domenico.
In: Angiogenesis, Vol. 11, No. 3, 09.2008, p. 215-221.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The discovery of the placental growth factor and its role in angiogenesis
T2 - A historical review
AU - Ribatti, Domenico
PY - 2008/9
Y1 - 2008/9
N2 - The placental growth factor (PlGF) is an angiogenic protein belonging to the vascular endothelial growth factor (VEGF) family, which was discovered in 1991 by an Italian scientist, Maria Graziella Persico. Dr Persico cloned and purified PlGF and determined its structure by crystallography resolution. Furthermore, she identified VEGF receptor-1 (VEGFR-1) as the receptor for PlGF, and in collaboration with Dr Peter Carmeliet in Leuven, she generated evidence that loss of PlGF does not affect development, reproduction, or postnatal life. PlGF is expressed primarily in the placenta and is up-regulated in several pathological conditions, although its role is still controversial. Some data in literature reported that PlGF enhances pathological angiogenesis by initiating a cross-talk between VEGFR-1 and VEGFR-2, whereas other studies did not confirm these findings. Regarding the potential therapeutic employment of PlGF, recent evidence has shown that an anti-PlGF antibody may act as a potent antiangiogenic agent, and that it has the advantage of minor toxicity when combined with anti-VEGF strategies.
AB - The placental growth factor (PlGF) is an angiogenic protein belonging to the vascular endothelial growth factor (VEGF) family, which was discovered in 1991 by an Italian scientist, Maria Graziella Persico. Dr Persico cloned and purified PlGF and determined its structure by crystallography resolution. Furthermore, she identified VEGF receptor-1 (VEGFR-1) as the receptor for PlGF, and in collaboration with Dr Peter Carmeliet in Leuven, she generated evidence that loss of PlGF does not affect development, reproduction, or postnatal life. PlGF is expressed primarily in the placenta and is up-regulated in several pathological conditions, although its role is still controversial. Some data in literature reported that PlGF enhances pathological angiogenesis by initiating a cross-talk between VEGFR-1 and VEGFR-2, whereas other studies did not confirm these findings. Regarding the potential therapeutic employment of PlGF, recent evidence has shown that an anti-PlGF antibody may act as a potent antiangiogenic agent, and that it has the advantage of minor toxicity when combined with anti-VEGF strategies.
KW - Angiogenesis
KW - Antiangiogenesis
KW - History of medicine
KW - Placental growth factor
KW - Vascular endothelial growth factor
UR - http://www.scopus.com/inward/record.url?scp=48749111875&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=48749111875&partnerID=8YFLogxK
U2 - 10.1007/s10456-008-9114-4
DO - 10.1007/s10456-008-9114-4
M3 - Article
C2 - 18568405
AN - SCOPUS:48749111875
VL - 11
SP - 215
EP - 221
JO - Angiogenesis
JF - Angiogenesis
SN - 0969-6970
IS - 3
ER -