The dismal outcome in patients with acute leukaemia who relapse after an autograft is improved if a second autograft or a matched allograft is performed

O. Ringdén, M. Labopin, N. C. Gorin, G. Meloni, D. Biaise, J. Reiffers, K. Carlson, L. Fouillard, F. Frassoni

Research output: Contribution to journalArticlepeer-review

Abstract

All patients receiving autografts for acute leukaemia in remission between 1 January 1981 and 31 December 1996 and reported to the European Group for Blood and Marrow Transplantation and had a relapse, were included. The patients underwent an allograft (n = 90, group A), were treated with chemotherapy (n = 2584, group B) or received a second autograft (n = 74, group C). The 2-year survival after relapse was 32 ± 5%, 11 ± 1% and 42 ± 6% in groups A, B and C, respectively. In group A, those with an HLA-A, -B and -DR compatible related or unrelated donor had a 2-year survival of 37 ± 7% compared to 13 ± 8% for those receiving a graft from an HLA mismatched donor (n = 20). The following factors were associated with better survival in multivariate analyses: an interval from first autograft to relapse > 5 months (P <0.00001), a first autograft performed later than 1991 (P <0.00001), patient age below 26 years (median, P <0.002), group B vs HLA mismatches from group A (P = 0.002), group C vs group B (P <0.005), patients who were not treated with total body irradiation at first autograft (P <0.02) and patients in first remission at first autograft (P = 0.02). To conclude, the poor outcome in these patients was improved if a second autograft was feasible (P <0.005), or if an HLA-matched allograft was performed (NS).

Original languageEnglish
Pages (from-to)1053-1058
Number of pages6
JournalBone Marrow Transplantation
Volume25
Issue number10
Publication statusPublished - 2000

Keywords

  • Acute leukaemia
  • Allogeneic bone marrow transplantation
  • Autologous stem cell transplantation
  • Relapse

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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