The distribution of apo C-II and apo C-III in very low density lipoproteins of normal and type iv subjects

A. L. Catapano

doi:10.1016/0021-9150(80)90182-3

The distribution of apo C-II and apo C-III in very low density lipoproteins of normal and type iv subjects

A. L. Catapano

IRCCS Multimedica

Research output: Contribution to journal › Article › peer-review

Abstract

The apoC-II/apoC-III ratio and the distribution of C apoproteins as percentage of the total protein in VLDL obtained from normolipidemic and type IV patients was studied by analytical isoelectrofocusing. While the percentage concentration of apoC-III was unchanged that of apoC-II was 9.2% of total protein in normal VLDL and only 7.4% in type IV VLDL (P <0.05). The apoC-II/apoC-III ratio significantly decreased in type IV patients. The analysis of VLDL subfractions obtained by density gradient ultracentrifugation gave essentially the same results. These data confirm the decrease of apoC-II as % of the protein in type IV VLDL and suggest that the decrease of the apoC-II/apoC-III ratio in type IV patients is related only to the decreased content of apoC-II. Whether the reduced apoC-II percentage amount or the decreased apoC-II/apoC-III ratio are related to the hypertriglyceridemia in type IV subjects is still unclear.

Original language	English
Pages (from-to)	419-424
Number of pages	6
Journal	Atherosclerosis
Volume	35
Issue number	4
DOIs	https://doi.org/10.1016/0021-9150(80)90182-3
Publication status	Published - 1980

Keywords

Apo CII
Apo CIII
Isoelectrofocusing
VLDL subtractions

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/0021-9150(80)90182-3

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title = "The distribution of apo C-II and apo C-III in very low density lipoproteins of normal and type iv subjects",

abstract = "The apoC-II/apoC-III ratio and the distribution of C apoproteins as percentage of the total protein in VLDL obtained from normolipidemic and type IV patients was studied by analytical isoelectrofocusing. While the percentage concentration of apoC-III was unchanged that of apoC-II was 9.2% of total protein in normal VLDL and only 7.4% in type IV VLDL (P <0.05). The apoC-II/apoC-III ratio significantly decreased in type IV patients. The analysis of VLDL subfractions obtained by density gradient ultracentrifugation gave essentially the same results. These data confirm the decrease of apoC-II as % of the protein in type IV VLDL and suggest that the decrease of the apoC-II/apoC-III ratio in type IV patients is related only to the decreased content of apoC-II. Whether the reduced apoC-II percentage amount or the decreased apoC-II/apoC-III ratio are related to the hypertriglyceridemia in type IV subjects is still unclear.",

keywords = "Apo CII, Apo CIII, Isoelectrofocusing, VLDL subtractions",

author = "Catapano, {A. L.}",

year = "1980",

doi = "10.1016/0021-9150(80)90182-3",

language = "English",

volume = "35",

pages = "419--424",

journal = "Atherosclerosis",

issn = "0021-9150",

publisher = "Elsevier Ireland Ltd",

number = "4",

}

TY - JOUR

T1 - The distribution of apo C-II and apo C-III in very low density lipoproteins of normal and type iv subjects

AU - Catapano, A. L.

PY - 1980

Y1 - 1980

N2 - The apoC-II/apoC-III ratio and the distribution of C apoproteins as percentage of the total protein in VLDL obtained from normolipidemic and type IV patients was studied by analytical isoelectrofocusing. While the percentage concentration of apoC-III was unchanged that of apoC-II was 9.2% of total protein in normal VLDL and only 7.4% in type IV VLDL (P <0.05). The apoC-II/apoC-III ratio significantly decreased in type IV patients. The analysis of VLDL subfractions obtained by density gradient ultracentrifugation gave essentially the same results. These data confirm the decrease of apoC-II as % of the protein in type IV VLDL and suggest that the decrease of the apoC-II/apoC-III ratio in type IV patients is related only to the decreased content of apoC-II. Whether the reduced apoC-II percentage amount or the decreased apoC-II/apoC-III ratio are related to the hypertriglyceridemia in type IV subjects is still unclear.

AB - The apoC-II/apoC-III ratio and the distribution of C apoproteins as percentage of the total protein in VLDL obtained from normolipidemic and type IV patients was studied by analytical isoelectrofocusing. While the percentage concentration of apoC-III was unchanged that of apoC-II was 9.2% of total protein in normal VLDL and only 7.4% in type IV VLDL (P <0.05). The apoC-II/apoC-III ratio significantly decreased in type IV patients. The analysis of VLDL subfractions obtained by density gradient ultracentrifugation gave essentially the same results. These data confirm the decrease of apoC-II as % of the protein in type IV VLDL and suggest that the decrease of the apoC-II/apoC-III ratio in type IV patients is related only to the decreased content of apoC-II. Whether the reduced apoC-II percentage amount or the decreased apoC-II/apoC-III ratio are related to the hypertriglyceridemia in type IV subjects is still unclear.

KW - Apo CII

KW - Apo CIII

KW - Isoelectrofocusing

KW - VLDL subtractions

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U2 - 10.1016/0021-9150(80)90182-3

DO - 10.1016/0021-9150(80)90182-3

M3 - Article

C2 - 7378122

AN - SCOPUS:0018833660

VL - 35

SP - 419

EP - 424

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 4

ER -

The distribution of apo C-II and apo C-III in very low density lipoproteins of normal and type iv subjects

Abstract

Keywords

ASJC Scopus subject areas

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