The distribution of the magnetic resonance imaging response to glatiramer acetate in multiple sclerosis

M. P. Sormani, P. Bruzzi, G. Comi, Massimo Filippi

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the distribution of the magnetic resonance imaging (MRI)-measured response to glatiramer acetate (GA) treatment in multiple sclerosis (MS) using data from a clinical trial of relapsing-remitting (RR) MS. A fixed and a random effects model were used to quantify the between-patient heterogeneity in treatment response, expressed as new enhancing lesion percentage reduction. In 95% of the patients, lesion reduction due to treatment was estimated to range between -20% and -54%, indicating a rather homogeneous effect of GA on MRI-measured disease activity in RRMS.

Original languageEnglish
Pages (from-to)447-449
Number of pages3
JournalMultiple Sclerosis Journal
Volume11
Issue number4
DOIs
Publication statusPublished - Aug 2005

Keywords

  • MRI lesions
  • Multiple sclerosis
  • Shape of GA effect

ASJC Scopus subject areas

  • Clinical Neurology

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