The distribution of the magnetic resonance imaging response to glatiramer acetate in multiple sclerosis

M. P. Sormani; P. Bruzzi; G. Comi; Massimo Filippi

doi:10.1191/1352458505ms1178oa

The distribution of the magnetic resonance imaging response to glatiramer acetate in multiple sclerosis

M. P. Sormani, P. Bruzzi, G. Comi, Massimo Filippi

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated the distribution of the magnetic resonance imaging (MRI)-measured response to glatiramer acetate (GA) treatment in multiple sclerosis (MS) using data from a clinical trial of relapsing-remitting (RR) MS. A fixed and a random effects model were used to quantify the between-patient heterogeneity in treatment response, expressed as new enhancing lesion percentage reduction. In 95% of the patients, lesion reduction due to treatment was estimated to range between -20% and -54%, indicating a rather homogeneous effect of GA on MRI-measured disease activity in RRMS.

Original language	English
Pages (from-to)	447-449
Number of pages	3
Journal	Multiple Sclerosis Journal
Volume	11
Issue number	4
DOIs	https://doi.org/10.1191/1352458505ms1178oa
Publication status	Published - Aug 2005

Keywords

MRI lesions
Multiple sclerosis
Shape of GA effect

ASJC Scopus subject areas

Clinical Neurology

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abstract = "We investigated the distribution of the magnetic resonance imaging (MRI)-measured response to glatiramer acetate (GA) treatment in multiple sclerosis (MS) using data from a clinical trial of relapsing-remitting (RR) MS. A fixed and a random effects model were used to quantify the between-patient heterogeneity in treatment response, expressed as new enhancing lesion percentage reduction. In 95% of the patients, lesion reduction due to treatment was estimated to range between -20% and -54%, indicating a rather homogeneous effect of GA on MRI-measured disease activity in RRMS.",

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AB - We investigated the distribution of the magnetic resonance imaging (MRI)-measured response to glatiramer acetate (GA) treatment in multiple sclerosis (MS) using data from a clinical trial of relapsing-remitting (RR) MS. A fixed and a random effects model were used to quantify the between-patient heterogeneity in treatment response, expressed as new enhancing lesion percentage reduction. In 95% of the patients, lesion reduction due to treatment was estimated to range between -20% and -54%, indicating a rather homogeneous effect of GA on MRI-measured disease activity in RRMS.

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KW - Shape of GA effect

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The distribution of the magnetic resonance imaging response to glatiramer acetate in multiple sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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