The dopamine-containing neuron: Maestro or simple musician in the orchestra of addiction?

Antonello Bonci, Giorgio Bernardi, Pernilla Grillner, Nicola B. Mercuri

Research output: Contribution to journalArticlepeer-review


Dopamine-containing neurons originating in the ventral tegmental area project primarily to the nucleus accumbens and the prefrontal cortex, forming the mesolimbic and mesocortical systems, respectively. Virtually every drug of abuse influences dopamine-mediated neurotransmission by affecting directly or indirectly the activity of these cells. Amphetamine and cocaine, in addition to opioids and nicotine, induce short- and long-term modifications of firing in the dopamine-containing neurons of the ventral mesencephalon. Although exposure to psychostimulants mainly depresses neuronal activity, nicotine and morphine enhance neuronal activity. However, under particular conditions, these drugs could cause different changes of firing. In this article, we propose that changes in the activity of dopamine-containing neurons are related to the processes of addiction. Therefore, we suggest that both the modulation of dopamine release in the extracellular space and transient or enduring changes in the firing of dopamine-containing neurons could be associated with important features of drugs of abuse.

Original languageEnglish
Pages (from-to)172-177
Number of pages6
JournalTrends in Pharmacological Sciences
Issue number4
Publication statusPublished - Apr 1 2003

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology


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