Abstract
The study investigated the effects of the dopamine-somatostatin chimeric compound BIM-23A760 on cell proliferation and apoptosis in cultured cells from human non-functioning pituitary tumors (NFPTs). Both BIM-23A760 and the dopaminergic agonist BIM-53097 induced a significant inhibition of cell proliferation associated with increased p27 expression, together with a significant increase in caspase-3 activity. Conversely, null or marginal effects were elicited by somatostatin analogs. Moreover, BIM-23A760 and BIM-53097 induced ERK1/2 and p38 phosphorylation and the blockade of these pathways prevented both the antiproliferative and the pro-apoptotic effects of these drugs. In conclusions the chimeric compound BIM-23A760 is able to exert cytostatic and cytotoxic effects in NFPTs, these phenomena being mainly mediated by DR2D and involving ERK1/2 and p38 pathways activation.
Original language | English |
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Pages (from-to) | 170-176 |
Number of pages | 7 |
Journal | Cancer Letters |
Volume | 288 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 28 2010 |
Keywords
- Apoptosis
- Cell proliferation
- Chimera
- Dopamine receptor
- Pituitary adenoma
- Somatostatin receptor
ASJC Scopus subject areas
- Cancer Research
- Oncology