The dopaminergic system in peripheral blood lymphocytes

From physiology to pharmacology and potential applications to neuropsychiatric disorders

Francesca R. Buttarelli, Alessandra Fanciulli, Clelia Pellicano, Francesco E. Pontieri

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Besides its action on the nervous system, dopamine (DA) plays a role on neural-immune interactions. Here we review the current evidence on the dopaminergic system in human peripheral blood lymphocytes (PBL). PBL synthesize DA through the tyrosine-hydroxylase/DOPA-decarboxylase pathway, and express DA receptors and DA transporter (DAT) on their plasma membrane. Stimulation of DA receptors on PBL membrane contributes to modulate the development and initiation of immune responses under physiological conditions and in immune system pathologies such as autoimmunity or immunodeficiency. The characterization of DA system in PBL gave rise to a further line of research investigating the feasibility of PBL as a cellular model for studying DA derangement in neuropsychiatric disorders. Several reports showed changes of the expression of DAT and/or DA receptors in PBL from patients suffering from several neuropsychiatric disorders, in particular parkinsonian syndromes, schizophrenia and drug- or alcohol-abuse. Despite some methodological and theoretical limitations, these findings suggest that PBL may prove a cellular tool with which to identify the derangement of DA transmission in neuropsychiatric diseases, as well as to monitor the effects of pharmacological treatments.

Original languageEnglish
Pages (from-to)278-288
Number of pages11
JournalCurrent Neuropharmacology
Volume9
Issue number2
DOIs
Publication statusPublished - Jun 2011

Fingerprint

Pharmacology
Lymphocytes
Dopamine
Dopamine Receptors
Dopamine Plasma Membrane Transport Proteins
Carboxy-Lyases
Tyrosine 3-Monooxygenase
Parkinsonian Disorders
Autoimmunity
Nervous System
Alcoholism
Immune System
Schizophrenia
Cell Membrane
Pathology
Membranes
Research
Pharmaceutical Preparations
Therapeutics

Keywords

  • Dopamine
  • Dopamine receptors
  • Dopamine transporter
  • Neuropsychiatric disorders
  • Peripheral blood lymphocytes

ASJC Scopus subject areas

  • Clinical Neurology
  • Pharmacology (medical)
  • Pharmacology
  • Neurology
  • Psychiatry and Mental health

Cite this

The dopaminergic system in peripheral blood lymphocytes : From physiology to pharmacology and potential applications to neuropsychiatric disorders. / Buttarelli, Francesca R.; Fanciulli, Alessandra; Pellicano, Clelia; Pontieri, Francesco E.

In: Current Neuropharmacology, Vol. 9, No. 2, 06.2011, p. 278-288.

Research output: Contribution to journalArticle

@article{f1bd7bfb92b44e7c8c1074189551de03,
title = "The dopaminergic system in peripheral blood lymphocytes: From physiology to pharmacology and potential applications to neuropsychiatric disorders",
abstract = "Besides its action on the nervous system, dopamine (DA) plays a role on neural-immune interactions. Here we review the current evidence on the dopaminergic system in human peripheral blood lymphocytes (PBL). PBL synthesize DA through the tyrosine-hydroxylase/DOPA-decarboxylase pathway, and express DA receptors and DA transporter (DAT) on their plasma membrane. Stimulation of DA receptors on PBL membrane contributes to modulate the development and initiation of immune responses under physiological conditions and in immune system pathologies such as autoimmunity or immunodeficiency. The characterization of DA system in PBL gave rise to a further line of research investigating the feasibility of PBL as a cellular model for studying DA derangement in neuropsychiatric disorders. Several reports showed changes of the expression of DAT and/or DA receptors in PBL from patients suffering from several neuropsychiatric disorders, in particular parkinsonian syndromes, schizophrenia and drug- or alcohol-abuse. Despite some methodological and theoretical limitations, these findings suggest that PBL may prove a cellular tool with which to identify the derangement of DA transmission in neuropsychiatric diseases, as well as to monitor the effects of pharmacological treatments.",
keywords = "Dopamine, Dopamine receptors, Dopamine transporter, Neuropsychiatric disorders, Peripheral blood lymphocytes",
author = "Buttarelli, {Francesca R.} and Alessandra Fanciulli and Clelia Pellicano and Pontieri, {Francesco E.}",
year = "2011",
month = "6",
doi = "10.2174/157015911795596612",
language = "English",
volume = "9",
pages = "278--288",
journal = "Current Neuropharmacology",
issn = "1570-159X",
publisher = "Bentham Science Publishers B.V.",
number = "2",

}

TY - JOUR

T1 - The dopaminergic system in peripheral blood lymphocytes

T2 - From physiology to pharmacology and potential applications to neuropsychiatric disorders

AU - Buttarelli, Francesca R.

AU - Fanciulli, Alessandra

AU - Pellicano, Clelia

AU - Pontieri, Francesco E.

PY - 2011/6

Y1 - 2011/6

N2 - Besides its action on the nervous system, dopamine (DA) plays a role on neural-immune interactions. Here we review the current evidence on the dopaminergic system in human peripheral blood lymphocytes (PBL). PBL synthesize DA through the tyrosine-hydroxylase/DOPA-decarboxylase pathway, and express DA receptors and DA transporter (DAT) on their plasma membrane. Stimulation of DA receptors on PBL membrane contributes to modulate the development and initiation of immune responses under physiological conditions and in immune system pathologies such as autoimmunity or immunodeficiency. The characterization of DA system in PBL gave rise to a further line of research investigating the feasibility of PBL as a cellular model for studying DA derangement in neuropsychiatric disorders. Several reports showed changes of the expression of DAT and/or DA receptors in PBL from patients suffering from several neuropsychiatric disorders, in particular parkinsonian syndromes, schizophrenia and drug- or alcohol-abuse. Despite some methodological and theoretical limitations, these findings suggest that PBL may prove a cellular tool with which to identify the derangement of DA transmission in neuropsychiatric diseases, as well as to monitor the effects of pharmacological treatments.

AB - Besides its action on the nervous system, dopamine (DA) plays a role on neural-immune interactions. Here we review the current evidence on the dopaminergic system in human peripheral blood lymphocytes (PBL). PBL synthesize DA through the tyrosine-hydroxylase/DOPA-decarboxylase pathway, and express DA receptors and DA transporter (DAT) on their plasma membrane. Stimulation of DA receptors on PBL membrane contributes to modulate the development and initiation of immune responses under physiological conditions and in immune system pathologies such as autoimmunity or immunodeficiency. The characterization of DA system in PBL gave rise to a further line of research investigating the feasibility of PBL as a cellular model for studying DA derangement in neuropsychiatric disorders. Several reports showed changes of the expression of DAT and/or DA receptors in PBL from patients suffering from several neuropsychiatric disorders, in particular parkinsonian syndromes, schizophrenia and drug- or alcohol-abuse. Despite some methodological and theoretical limitations, these findings suggest that PBL may prove a cellular tool with which to identify the derangement of DA transmission in neuropsychiatric diseases, as well as to monitor the effects of pharmacological treatments.

KW - Dopamine

KW - Dopamine receptors

KW - Dopamine transporter

KW - Neuropsychiatric disorders

KW - Peripheral blood lymphocytes

UR - http://www.scopus.com/inward/record.url?scp=79958167848&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958167848&partnerID=8YFLogxK

U2 - 10.2174/157015911795596612

DO - 10.2174/157015911795596612

M3 - Article

VL - 9

SP - 278

EP - 288

JO - Current Neuropharmacology

JF - Current Neuropharmacology

SN - 1570-159X

IS - 2

ER -