Abstract
Background: Previous studies have provided limited support to the association between tobacco smoking and lymphomas with weak evidence of a dose-response relationship. Methods: We investigated the relationship between tobacco smoking and risk of non-Hodgkin lymphomas (NHL) and Hodgkin lymphomas (HL) through logistic regression spline models. Data were derived from an Italian hospitalbased case-control study (1999-2014), which enrolled 571 NHLs, 188 HLs, and 1004 cancer-free controls. Smoking habits and other lifestyle factors were assessed through a validated questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by logistic regression, adjusting for potential confounders. Results: Compared to never smokers, people smoking ≥15 cigarettes/day showed increased risks of both NHL (OR = 1.42, 95% CI: 1.02, 1.97) and HL (OR = 2.47, 95% CI: 1.25, 4.87); the risk was particularly elevated for follicular NHL (OR = 2.43; 95% CI:1.31-4.51) and mixed cellularity HL (OR = 5.60, 95% CI: 1.31, 23.97). No excess risk emerged for former smokers or people smoking < 15 cigarettes/day. Spline analyses showed a positive dose-response relationship with significant increases in NHL and HL risks starting from 15 and 21 cigarettes/day, respectively, with the most evident effects for follicular NHL and mixed cellularity HL. Smoking duration was significantly associated with the HL risk only (OR = 2.15, 95% CI: 1.16, 3.99). Conclusions: These findings support a role of tobacco smoking in the etiology of both NHL and HL, providing evidence of a direct association of risk with smoking intensity.
| Original language | English |
|---|---|
| Article number | 421 |
| Journal | BMC Cancer |
| Volume | 17 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2017 |
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Keywords
- Case-control study
- Dose-response relationship
- Hodgkin lymphoma
- Non-Hodgkin lymphoma
- Spline models
- Tobacco smoking
ASJC Scopus subject areas
- Oncology
- Genetics
- Cancer Research
Cite this
The dose-response relationship between tobacco smoking and the risk of lymphomas : A case-control study. / Taborelli, Martina; Montella, Maurizio; Libra, Massimo; Tedeschi, Rosamaria; Crispo, Anna; Grimaldi, Maria; Maso, Luigino Dal; Serraino, Diego; Polesel, Jerry.
In: BMC Cancer, Vol. 17, No. 1, 421, 2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The dose-response relationship between tobacco smoking and the risk of lymphomas
T2 - A case-control study
AU - Taborelli, Martina
AU - Montella, Maurizio
AU - Libra, Massimo
AU - Tedeschi, Rosamaria
AU - Crispo, Anna
AU - Grimaldi, Maria
AU - Maso, Luigino Dal
AU - Serraino, Diego
AU - Polesel, Jerry
PY - 2017
Y1 - 2017
N2 - Background: Previous studies have provided limited support to the association between tobacco smoking and lymphomas with weak evidence of a dose-response relationship. Methods: We investigated the relationship between tobacco smoking and risk of non-Hodgkin lymphomas (NHL) and Hodgkin lymphomas (HL) through logistic regression spline models. Data were derived from an Italian hospitalbased case-control study (1999-2014), which enrolled 571 NHLs, 188 HLs, and 1004 cancer-free controls. Smoking habits and other lifestyle factors were assessed through a validated questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by logistic regression, adjusting for potential confounders. Results: Compared to never smokers, people smoking ≥15 cigarettes/day showed increased risks of both NHL (OR = 1.42, 95% CI: 1.02, 1.97) and HL (OR = 2.47, 95% CI: 1.25, 4.87); the risk was particularly elevated for follicular NHL (OR = 2.43; 95% CI:1.31-4.51) and mixed cellularity HL (OR = 5.60, 95% CI: 1.31, 23.97). No excess risk emerged for former smokers or people smoking < 15 cigarettes/day. Spline analyses showed a positive dose-response relationship with significant increases in NHL and HL risks starting from 15 and 21 cigarettes/day, respectively, with the most evident effects for follicular NHL and mixed cellularity HL. Smoking duration was significantly associated with the HL risk only (OR = 2.15, 95% CI: 1.16, 3.99). Conclusions: These findings support a role of tobacco smoking in the etiology of both NHL and HL, providing evidence of a direct association of risk with smoking intensity.
AB - Background: Previous studies have provided limited support to the association between tobacco smoking and lymphomas with weak evidence of a dose-response relationship. Methods: We investigated the relationship between tobacco smoking and risk of non-Hodgkin lymphomas (NHL) and Hodgkin lymphomas (HL) through logistic regression spline models. Data were derived from an Italian hospitalbased case-control study (1999-2014), which enrolled 571 NHLs, 188 HLs, and 1004 cancer-free controls. Smoking habits and other lifestyle factors were assessed through a validated questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by logistic regression, adjusting for potential confounders. Results: Compared to never smokers, people smoking ≥15 cigarettes/day showed increased risks of both NHL (OR = 1.42, 95% CI: 1.02, 1.97) and HL (OR = 2.47, 95% CI: 1.25, 4.87); the risk was particularly elevated for follicular NHL (OR = 2.43; 95% CI:1.31-4.51) and mixed cellularity HL (OR = 5.60, 95% CI: 1.31, 23.97). No excess risk emerged for former smokers or people smoking < 15 cigarettes/day. Spline analyses showed a positive dose-response relationship with significant increases in NHL and HL risks starting from 15 and 21 cigarettes/day, respectively, with the most evident effects for follicular NHL and mixed cellularity HL. Smoking duration was significantly associated with the HL risk only (OR = 2.15, 95% CI: 1.16, 3.99). Conclusions: These findings support a role of tobacco smoking in the etiology of both NHL and HL, providing evidence of a direct association of risk with smoking intensity.
KW - Case-control study
KW - Dose-response relationship
KW - Hodgkin lymphoma
KW - Non-Hodgkin lymphoma
KW - Spline models
KW - Tobacco smoking
UR - http://www.scopus.com/inward/record.url?scp=85027551350&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85027551350&partnerID=8YFLogxK
U2 - 10.1186/s12885-017-3414-2
DO - 10.1186/s12885-017-3414-2
M3 - Article
AN - SCOPUS:85027551350
VL - 17
JO - BMC Cancer
JF - BMC Cancer
SN - 1471-2407
IS - 1
M1 - 421
ER -