The dose-response relationship between tobacco smoking and the risk of lymphomas: A case-control study

M. Taborelli, M. Montella, M. Libra, R. Tedeschi, A. Crispo, M. Grimaldi, L.D. Maso, D. Serraino, J. Polesel

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Previous studies have provided limited support to the association between tobacco smoking and lymphomas with weak evidence of a dose-response relationship. Methods: We investigated the relationship between tobacco smoking and risk of non-Hodgkin lymphomas (NHL) and Hodgkin lymphomas (HL) through logistic regression spline models. Data were derived from an Italian hospitalbased case-control study (1999-2014), which enrolled 571 NHLs, 188 HLs, and 1004 cancer-free controls. Smoking habits and other lifestyle factors were assessed through a validated questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by logistic regression, adjusting for potential confounders. Results: Compared to never smokers, people smoking ≥15 cigarettes/day showed increased risks of both NHL (OR = 1.42, 95% CI: 1.02, 1.97) and HL (OR = 2.47, 95% CI: 1.25, 4.87); the risk was particularly elevated for follicular NHL (OR = 2.43; 95% CI:1.31-4.51) and mixed cellularity HL (OR = 5.60, 95% CI: 1.31, 23.97). No excess risk emerged for former smokers or people smoking <15 cigarettes/day. Spline analyses showed a positive dose-response relationship with significant increases in NHL and HL risks starting from 15 and 21 cigarettes/day, respectively, with the most evident effects for follicular NHL and mixed cellularity HL. Smoking duration was significantly associated with the HL risk only (OR = 2.15, 95% CI: 1.16, 3.99). Conclusions: These findings support a role of tobacco smoking in the etiology of both NHL and HL, providing evidence of a direct association of risk with smoking intensity. © The Author(s). 2017.
Original languageEnglish
Article number421
Number of pages9
JournalBMC Cancer
Volume17
Issue number1
DOIs
Publication statusPublished - 2017

Fingerprint

Hodgkin Disease
Case-Control Studies
Lymphoma
Smoking
Non-Hodgkin's Lymphoma
Odds Ratio
Confidence Intervals
Follicular Lymphoma
Tobacco Products
Logistic Models
Habits
Life Style
Neoplasms

Keywords

  • Case-control study
  • Dose-response relationship
  • Hodgkin lymphoma
  • Non-Hodgkin lymphoma
  • Spline models
  • Tobacco smoking

Cite this

The dose-response relationship between tobacco smoking and the risk of lymphomas: A case-control study. / Taborelli, M.; Montella, M.; Libra, M.; Tedeschi, R.; Crispo, A.; Grimaldi, M.; Maso, L.D.; Serraino, D.; Polesel, J.

In: BMC Cancer, Vol. 17, No. 1, 421, 2017.

Research output: Contribution to journalArticle

@article{4320de32161d442393b6b00f1998ab3a,
title = "The dose-response relationship between tobacco smoking and the risk of lymphomas: A case-control study",
abstract = "Background: Previous studies have provided limited support to the association between tobacco smoking and lymphomas with weak evidence of a dose-response relationship. Methods: We investigated the relationship between tobacco smoking and risk of non-Hodgkin lymphomas (NHL) and Hodgkin lymphomas (HL) through logistic regression spline models. Data were derived from an Italian hospitalbased case-control study (1999-2014), which enrolled 571 NHLs, 188 HLs, and 1004 cancer-free controls. Smoking habits and other lifestyle factors were assessed through a validated questionnaire. Odds ratios (OR) and 95{\%} confidence intervals (CI) were estimated by logistic regression, adjusting for potential confounders. Results: Compared to never smokers, people smoking ≥15 cigarettes/day showed increased risks of both NHL (OR = 1.42, 95{\%} CI: 1.02, 1.97) and HL (OR = 2.47, 95{\%} CI: 1.25, 4.87); the risk was particularly elevated for follicular NHL (OR = 2.43; 95{\%} CI:1.31-4.51) and mixed cellularity HL (OR = 5.60, 95{\%} CI: 1.31, 23.97). No excess risk emerged for former smokers or people smoking <15 cigarettes/day. Spline analyses showed a positive dose-response relationship with significant increases in NHL and HL risks starting from 15 and 21 cigarettes/day, respectively, with the most evident effects for follicular NHL and mixed cellularity HL. Smoking duration was significantly associated with the HL risk only (OR = 2.15, 95{\%} CI: 1.16, 3.99). Conclusions: These findings support a role of tobacco smoking in the etiology of both NHL and HL, providing evidence of a direct association of risk with smoking intensity. {\circledC} The Author(s). 2017.",
keywords = "Case-control study, Dose-response relationship, Hodgkin lymphoma, Non-Hodgkin lymphoma, Spline models, Tobacco smoking",
author = "M. Taborelli and M. Montella and M. Libra and R. Tedeschi and A. Crispo and M. Grimaldi and L.D. Maso and D. Serraino and J. Polesel",
note = "Export Date: 20 February 2018 CODEN: BCMAC Correspondence Address: Polesel, J.; Unit of Cancer Epidemiology, CRO Aviano National Cancer Institute, Via Franco Gallini 2, Italy; email: polesel@cro.it",
year = "2017",
doi = "10.1186/s12885-017-3414-2",
language = "English",
volume = "17",
journal = "BMC Cancer",
issn = "1471-2407",
publisher = "BioMed Central Ltd.",
number = "1",

}

TY - JOUR

T1 - The dose-response relationship between tobacco smoking and the risk of lymphomas: A case-control study

AU - Taborelli, M.

AU - Montella, M.

AU - Libra, M.

AU - Tedeschi, R.

AU - Crispo, A.

AU - Grimaldi, M.

AU - Maso, L.D.

AU - Serraino, D.

AU - Polesel, J.

N1 - Export Date: 20 February 2018 CODEN: BCMAC Correspondence Address: Polesel, J.; Unit of Cancer Epidemiology, CRO Aviano National Cancer Institute, Via Franco Gallini 2, Italy; email: polesel@cro.it

PY - 2017

Y1 - 2017

N2 - Background: Previous studies have provided limited support to the association between tobacco smoking and lymphomas with weak evidence of a dose-response relationship. Methods: We investigated the relationship between tobacco smoking and risk of non-Hodgkin lymphomas (NHL) and Hodgkin lymphomas (HL) through logistic regression spline models. Data were derived from an Italian hospitalbased case-control study (1999-2014), which enrolled 571 NHLs, 188 HLs, and 1004 cancer-free controls. Smoking habits and other lifestyle factors were assessed through a validated questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by logistic regression, adjusting for potential confounders. Results: Compared to never smokers, people smoking ≥15 cigarettes/day showed increased risks of both NHL (OR = 1.42, 95% CI: 1.02, 1.97) and HL (OR = 2.47, 95% CI: 1.25, 4.87); the risk was particularly elevated for follicular NHL (OR = 2.43; 95% CI:1.31-4.51) and mixed cellularity HL (OR = 5.60, 95% CI: 1.31, 23.97). No excess risk emerged for former smokers or people smoking <15 cigarettes/day. Spline analyses showed a positive dose-response relationship with significant increases in NHL and HL risks starting from 15 and 21 cigarettes/day, respectively, with the most evident effects for follicular NHL and mixed cellularity HL. Smoking duration was significantly associated with the HL risk only (OR = 2.15, 95% CI: 1.16, 3.99). Conclusions: These findings support a role of tobacco smoking in the etiology of both NHL and HL, providing evidence of a direct association of risk with smoking intensity. © The Author(s). 2017.

AB - Background: Previous studies have provided limited support to the association between tobacco smoking and lymphomas with weak evidence of a dose-response relationship. Methods: We investigated the relationship between tobacco smoking and risk of non-Hodgkin lymphomas (NHL) and Hodgkin lymphomas (HL) through logistic regression spline models. Data were derived from an Italian hospitalbased case-control study (1999-2014), which enrolled 571 NHLs, 188 HLs, and 1004 cancer-free controls. Smoking habits and other lifestyle factors were assessed through a validated questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by logistic regression, adjusting for potential confounders. Results: Compared to never smokers, people smoking ≥15 cigarettes/day showed increased risks of both NHL (OR = 1.42, 95% CI: 1.02, 1.97) and HL (OR = 2.47, 95% CI: 1.25, 4.87); the risk was particularly elevated for follicular NHL (OR = 2.43; 95% CI:1.31-4.51) and mixed cellularity HL (OR = 5.60, 95% CI: 1.31, 23.97). No excess risk emerged for former smokers or people smoking <15 cigarettes/day. Spline analyses showed a positive dose-response relationship with significant increases in NHL and HL risks starting from 15 and 21 cigarettes/day, respectively, with the most evident effects for follicular NHL and mixed cellularity HL. Smoking duration was significantly associated with the HL risk only (OR = 2.15, 95% CI: 1.16, 3.99). Conclusions: These findings support a role of tobacco smoking in the etiology of both NHL and HL, providing evidence of a direct association of risk with smoking intensity. © The Author(s). 2017.

KW - Case-control study

KW - Dose-response relationship

KW - Hodgkin lymphoma

KW - Non-Hodgkin lymphoma

KW - Spline models

KW - Tobacco smoking

U2 - 10.1186/s12885-017-3414-2

DO - 10.1186/s12885-017-3414-2

M3 - Article

VL - 17

JO - BMC Cancer

JF - BMC Cancer

SN - 1471-2407

IS - 1

M1 - 421

ER -