The Dual Roles of NRF2 in Cancer

Silvia Menegon, Amedeo Columbano, Silvia Giordano

Research output: Contribution to journalReview article

Abstract

NRF2 has been traditionally considered as a tumor suppressor because its cytoprotective functions are deemed to be the main cellular defense mechanism against exogenous and endogenous insults, including xenobiotics and oxidative stress. However, several recent studies demonstrate that hyperactivation of the NRF2 pathway creates an environment that favors the survival of normal as well as malignant cells, protecting them against oxidative stress, chemotherapeutic agents, and radiotherapy. In a rapidly advancing field, this review summarizes some of the known mechanisms by which NRF2 can exert its oncogenic functions, and describes the current status of NRF2 inhibitors, providing a clear rationale for the consideration of NRF2 as a powerful putative therapeutic target in cancer treatment.

Original languageEnglish
Pages (from-to)578-593
Number of pages16
JournalTrends in Molecular Medicine
Volume22
Issue number7
DOIs
Publication statusPublished - Jul 1 2016

Keywords

  • antioxidant response
  • KEAP1
  • mutations
  • NRF2

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine

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