Abstract
Stem cell transplantation after myocardial infarction has been claimed to restore cardiac function, but the underlying mechanism remains unclear. A minority of transplanted cells become adherent in heart tissue and contribute to neovascularization, whereas many donor cells die from apoptosis. We propose that apoptosis of transplanted cells modulates local tissue reactions. Apoptotic cells impact on immune reactivity by down-regulating innate and adaptive immunity, deactivating macrophages and dendritic cells, and stimulating regulatory T cells. This leads to reduced scar formation, repressed myocardial apoptosis, and improved cardiac outcome.
| Original language | English |
|---|---|
| Pages (from-to) | 1799-1802 |
| Number of pages | 4 |
| Journal | Journal of the American College of Cardiology |
| Volume | 46 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Nov 15 2005 |
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ASJC Scopus subject areas
- Nursing(all)
Cite this
The dying stem cell hypothesis : Immune modulation as a novel mechanism for progenitor cell therapy in cardiac muscle. / Thum, Thomas; Bauersachs, Johann; Poole-Wilson, Philip A.; Volk, Hans Dieter; Anker, Stefan D.
In: Journal of the American College of Cardiology, Vol. 46, No. 10, 15.11.2005, p. 1799-1802.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The dying stem cell hypothesis
T2 - Immune modulation as a novel mechanism for progenitor cell therapy in cardiac muscle
AU - Thum, Thomas
AU - Bauersachs, Johann
AU - Poole-Wilson, Philip A.
AU - Volk, Hans Dieter
AU - Anker, Stefan D.
PY - 2005/11/15
Y1 - 2005/11/15
N2 - Stem cell transplantation after myocardial infarction has been claimed to restore cardiac function, but the underlying mechanism remains unclear. A minority of transplanted cells become adherent in heart tissue and contribute to neovascularization, whereas many donor cells die from apoptosis. We propose that apoptosis of transplanted cells modulates local tissue reactions. Apoptotic cells impact on immune reactivity by down-regulating innate and adaptive immunity, deactivating macrophages and dendritic cells, and stimulating regulatory T cells. This leads to reduced scar formation, repressed myocardial apoptosis, and improved cardiac outcome.
AB - Stem cell transplantation after myocardial infarction has been claimed to restore cardiac function, but the underlying mechanism remains unclear. A minority of transplanted cells become adherent in heart tissue and contribute to neovascularization, whereas many donor cells die from apoptosis. We propose that apoptosis of transplanted cells modulates local tissue reactions. Apoptotic cells impact on immune reactivity by down-regulating innate and adaptive immunity, deactivating macrophages and dendritic cells, and stimulating regulatory T cells. This leads to reduced scar formation, repressed myocardial apoptosis, and improved cardiac outcome.
UR - http://www.scopus.com/inward/record.url?scp=27644532831&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27644532831&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2005.07.053
DO - 10.1016/j.jacc.2005.07.053
M3 - Article
C2 - 16286162
AN - SCOPUS:27644532831
VL - 46
SP - 1799
EP - 1802
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
SN - 0735-1097
IS - 10
ER -