The dying stem cell hypothesis: Immune modulation as a novel mechanism for progenitor cell therapy in cardiac muscle

Thomas Thum; Johann Bauersachs; Philip A. Poole-Wilson; Hans Dieter Volk; Stefan D. Anker

doi:10.1016/j.jacc.2005.07.053

The dying stem cell hypothesis: Immune modulation as a novel mechanism for progenitor cell therapy in cardiac muscle

Thomas Thum, Johann Bauersachs, Philip A. Poole-Wilson, Hans Dieter Volk, Stefan D. Anker

Istituto San Raffaele Pisana

Research output: Contribution to journal › Article › peer-review

Abstract

Stem cell transplantation after myocardial infarction has been claimed to restore cardiac function, but the underlying mechanism remains unclear. A minority of transplanted cells become adherent in heart tissue and contribute to neovascularization, whereas many donor cells die from apoptosis. We propose that apoptosis of transplanted cells modulates local tissue reactions. Apoptotic cells impact on immune reactivity by down-regulating innate and adaptive immunity, deactivating macrophages and dendritic cells, and stimulating regulatory T cells. This leads to reduced scar formation, repressed myocardial apoptosis, and improved cardiac outcome.

Original language	English
Pages (from-to)	1799-1802
Number of pages	4
Journal	Journal of the American College of Cardiology
Volume	46
Issue number	10
DOIs	https://doi.org/10.1016/j.jacc.2005.07.053
Publication status	Published - Nov 15 2005

ASJC Scopus subject areas

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The dying stem cell hypothesis : Immune modulation as a novel mechanism for progenitor cell therapy in cardiac muscle. / Thum, Thomas; Bauersachs, Johann; Poole-Wilson, Philip A.; Volk, Hans Dieter; Anker, Stefan D.

In: Journal of the American College of Cardiology, Vol. 46, No. 10, 15.11.2005, p. 1799-1802.

Research output: Contribution to journal › Article › peer-review

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