The E-selectin polymorphism and it's possible role in restenosis

M. Rauchhaus, S. D. Anker, K. Handschug, W. Teichmann, C. Glaeser

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Abstract

Background: An 128-serine/argjnine polymorphism of the EGF-like domain of E-selectin was found to be associated with a higher risk of early severe atherosclerosis. Methods: This study was designed to look at the distribution of the E-selectin polymorphism in patients who underwent successful percutaneous transluminal coronary angioplasty (PTCA) after myocardial infarktion. PCR was used for genetic analysis in 102 control subjects (92 male) compared to 54 consecutive coronary artery disease (CAD) patients (42 male). Patients were characterised by risk factors, clinical diagnosis and were followed-up over 36 months. In 38 CAD patients (70%) a repeated PTCA was necessary and restenosis was defined as >50% luminal diameter stenosis at the side of angioplasty (two independent examiner). Results: No significant differences were found in the arginine allele frequency (12% vs 9%, p=0.49) and the serine/arginine genotype frequency (24 vs 14%, p=0.08) between patients and controls (frequencies also not influenced by risk factor status). However, in the subgroup of 20 patients (37%) with documented restenosis an increased frequency of the serine/arginine genotype (40%, p

Original languageEnglish
JournalHeart
Volume79
Issue numberSUPPL. 1
Publication statusPublished - May 1998

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Rauchhaus, M., Anker, S. D., Handschug, K., Teichmann, W., & Glaeser, C. (1998). The E-selectin polymorphism and it's possible role in restenosis. Heart, 79(SUPPL. 1).