The E27 β2-adrenergic receptor polymorphism reduces the risk of myocardial infarction in dyslipidemic young males

G. Sala, A. Di Castelnuovo, L. Cuomo, M. Gattone, P. Giannuzzi, L. Iacoviello, A. De Blasi

Research output: Contribution to journalArticle

Abstract

In the present study we evaluated whether two polymorphisms of β2-adrenergic receptors (β2-AR) gene (R16G and Q27E) could modify the risk of myocardial infarction (MI). Using a case-control design, we analyzed the data from 125 male patients who had experienced a first episode of MI before the age of 45 years and 108 male controls matched for age. The allele frequencies for R16G and Q27E were: G16=0.56 and E27=0.36 in patients with MI and G16=0.61 and E27=0.42 in the control group. There was a trend (not statistically significant) of decreasing MI risk according to E27 or G16 alleles. Combined effect between E27 allele and history of dyslipidemia has been observed. Whereas dyslipidemia conferred a relative risk of MI of 4.8 (P2-adrenergic receptor has a significant protective effect on MI in dyslipidemic young male.

Original languageEnglish
Pages (from-to)231-233
Number of pages3
JournalThrombosis and Haemostasis
Volume85
Issue number2
Publication statusPublished - 2001

Keywords

  • β-Adrenergic receptor polymorphisms
  • Dyslipidemia
  • Myocardial infarction

ASJC Scopus subject areas

  • Hematology

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