The early administration of Lactobacillus reuteri DSM 17938 controls regurgitation episodes in full-term breastfed infants

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6 Citations (Scopus)

Abstract

Forty breastfed full-term infants were randomly, double blind assigned to receive orally Lactobacillus reuteri (L. reuteri) DSM 17938, 5 drops/daily (108 colony-forming units), for 4 weeks (n = 20) or an identical placebo (n = 20), starting before third day of life. They underwent basal and final visit to monitor growth parameters and gastrointestinal (GI) disease. Parents registered daily: crying minutes, stool frequency and consistency, numbers of regurgitations, adverse events. Secretory IgA (sIgA) has been measured in saliva on 28th day. Treated infants demonstrated a reduction in daily regurgitations at the end of treatment (p = 0.02), three neonates in the placebo group only needed simethicone for GI pain, sIgA level was similar in both groups. Random casualty produced an unbalanced gender distribution in the groups, but this bias did not affect the results. Therefore, early administration of L. reuteri DSM 17938 resulted beneficial in preventing regurgitation episodes during the first month of life.

Original languageEnglish
Pages (from-to)646-648
Number of pages3
JournalInternational Journal of Food Sciences and Nutrition
Volume65
Issue number5
DOIs
Publication statusPublished - 2014

Fingerprint

Lactobacillus reuteri
Secretory Immunoglobulin A
simethicone
placebos
Simethicone
Placebos
Crying
Gastrointestinal Diseases
saliva
digestive system diseases
Saliva
pain
neonates
Stem Cells
Parents
Newborn Infant
Pain
gender
Growth
Therapeutics

Keywords

  • Infants
  • Lactobacillus reuteri DSM 17938
  • Neonatal regurgitation
  • SIgA

ASJC Scopus subject areas

  • Food Science
  • Medicine(all)

Cite this

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title = "The early administration of Lactobacillus reuteri DSM 17938 controls regurgitation episodes in full-term breastfed infants",
abstract = "Forty breastfed full-term infants were randomly, double blind assigned to receive orally Lactobacillus reuteri (L. reuteri) DSM 17938, 5 drops/daily (108 colony-forming units), for 4 weeks (n = 20) or an identical placebo (n = 20), starting before third day of life. They underwent basal and final visit to monitor growth parameters and gastrointestinal (GI) disease. Parents registered daily: crying minutes, stool frequency and consistency, numbers of regurgitations, adverse events. Secretory IgA (sIgA) has been measured in saliva on 28th day. Treated infants demonstrated a reduction in daily regurgitations at the end of treatment (p = 0.02), three neonates in the placebo group only needed simethicone for GI pain, sIgA level was similar in both groups. Random casualty produced an unbalanced gender distribution in the groups, but this bias did not affect the results. Therefore, early administration of L. reuteri DSM 17938 resulted beneficial in preventing regurgitation episodes during the first month of life.",
keywords = "Infants, Lactobacillus reuteri DSM 17938, Neonatal regurgitation, SIgA",
author = "Francesca Garofoli and Elisa Civardi and Flavia Indrio and Iolanda Mazzucchelli and Micol Angelini and Carmine Tinelli and Mauro Stronati",
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AU - Garofoli, Francesca

AU - Civardi, Elisa

AU - Indrio, Flavia

AU - Mazzucchelli, Iolanda

AU - Angelini, Micol

AU - Tinelli, Carmine

AU - Stronati, Mauro

PY - 2014

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N2 - Forty breastfed full-term infants were randomly, double blind assigned to receive orally Lactobacillus reuteri (L. reuteri) DSM 17938, 5 drops/daily (108 colony-forming units), for 4 weeks (n = 20) or an identical placebo (n = 20), starting before third day of life. They underwent basal and final visit to monitor growth parameters and gastrointestinal (GI) disease. Parents registered daily: crying minutes, stool frequency and consistency, numbers of regurgitations, adverse events. Secretory IgA (sIgA) has been measured in saliva on 28th day. Treated infants demonstrated a reduction in daily regurgitations at the end of treatment (p = 0.02), three neonates in the placebo group only needed simethicone for GI pain, sIgA level was similar in both groups. Random casualty produced an unbalanced gender distribution in the groups, but this bias did not affect the results. Therefore, early administration of L. reuteri DSM 17938 resulted beneficial in preventing regurgitation episodes during the first month of life.

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