Die frühzeitige Elimination der Amanita Toxine in der Therapie der Knollenblätterpilzvergiftung

Translated title of the contribution: The early removal of amatoxins in the treatment of amanita phalloides poisoning

M. Langer, S. Vesconi, G. Iapichino, D. Costantino, D. Radrizzani

Research output: Contribution to journalArticlepeer-review


In a 3 year period (1975-77) 50 patients have been admitted to the I.C.U. of Polyclinic Hospital of Milan for poisoning from mushrooms of Amanita genus. In 47 cases the diagnosis was confirmed "a posteriori" by serum or urinary detection of amatoxins and/or by clinical evidence of typical liver injury. Besides the symptomatologic support, the therapeutic treatment included combined removal procedures, such as peritoneal dialysis, plasmapheresis, forced diuresis. The detection by radioimmunoassay of amatoxins [6] in the serum and in the urine of these patients proves that this therapeutic treatment can be effective within about 36 hours from ingestion time. The intensive medical care and the removal approach yielded as the whole favourable results in our patients (overall mortality was 6 patients, i.e. 12,7%). It should moreover be emphasized that of the 35 patients, who had been treated with early removal techniques, 12 with ascertained amanita poisoning, had neither clinical nor biochemical evidence of hepatic damage; 14 had a moderate liver damage; 9 experienced a severe liver failure and hepatic coma occurred in 4 of the latter. These poor results can be ascribed to the severity of the poisoning as well as to a peculiar kinetic of amatoxins in each subject.

Translated title of the contributionThe early removal of amatoxins in the treatment of amanita phalloides poisoning
Original languageGerman
Pages (from-to)117-123
Number of pages7
JournalKlinische Wochenschrift
Issue number3
Publication statusPublished - Feb 1980


  • Amanita phalloides poisoning
  • Amatoxins
  • Diuresis forced
  • Peritoneal dialysis
  • Pharmacodynamics
  • Plasmapheresis

ASJC Scopus subject areas

  • Medicine(all)


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