The ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K121Q polymorphism modulates the beneficial effect of weight loss on fasting glucose in non-diabetic individuals

M. Maranghi, S. Prudente, L. D'Erasmo, E. Morini, E. Ciociola, P. Coletta, A. Verrienti, S. Arciello, M. Copetti, F. Pellegrini, S. A. Santini, S. Morano, S. Filetti, V. Trischitta

Research output: Contribution to journalArticlepeer-review

Abstract

Background and aims: Several studies have reported that the ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K121Q polymorphism (rs1044498) interacts with increased adiposity in affecting glucose homeostasis and insulin sensitivity. Conversely, one would expect that the amelioration of glucose homeostasis observed after weight loss is modulated by the ENPP1 K121Q polymorphism. The aim of our study was to test such hypothesis, in non-diabetic overweight-obese individuals. Methods and results: Two hundred eleven non-diabetic overweight-obese individuals were studied. Body mass index (BMI), fasting glucose, homeostasis model assessment of insulin resistance (HOMA-IR index) and lipid levels were obtained before and after 6-week lifestyle intervention (LI; diet and exercise) and their changes calculated as baseline minus 6-week values. LI decreased BMI, glucose, HOMA-IR and triglyceride levels (p

Original languageEnglish
Pages (from-to)505-510
Number of pages6
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume23
Issue number6
DOIs
Publication statusPublished - Jun 2013

Keywords

  • Gene-treatment interaction
  • Insulin resistance
  • Insulin signalling
  • Lifestyle intervention
  • Overweight-obesity
  • Prevention of type 2 diabetes mellitus

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

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