TY - JOUR
T1 - The effect of acute administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on humoral antibody production and cell-mediated activities in mice.
AU - Vecchi, A.
AU - Mantovani, A.
AU - Sironi, M.
AU - Luini, W.
AU - Spreafico, F.
AU - Garattini, S.
PY - 1980
Y1 - 1980
N2 - The effect of single doses of TCDD (1.2, 6 or 30 gamma/kg) on several immune parameters has been investigated in young adult C57B1/6 mice. TCDD profoundly suppressed the primary and secondary humoral response to T-dependent (sheep erythrocytes, SRBC) and T-independent (Type III pneumococcal polysaccharide, S III) antigens. In vitro lymphoproliferative responses to Concanavallin A (Con A) and bacterial lypopolysaccharide (LPS), and macrophage and natural killer (NK) cell-mediated cytotoxicity were not significantly affected per unit number of lymphoid cells. Moreover, the ability of splenocytes from TCDD treated animals to mediate a graft versus host (GVH) reaction was not impaired.
AB - The effect of single doses of TCDD (1.2, 6 or 30 gamma/kg) on several immune parameters has been investigated in young adult C57B1/6 mice. TCDD profoundly suppressed the primary and secondary humoral response to T-dependent (sheep erythrocytes, SRBC) and T-independent (Type III pneumococcal polysaccharide, S III) antigens. In vitro lymphoproliferative responses to Concanavallin A (Con A) and bacterial lypopolysaccharide (LPS), and macrophage and natural killer (NK) cell-mediated cytotoxicity were not significantly affected per unit number of lymphoid cells. Moreover, the ability of splenocytes from TCDD treated animals to mediate a graft versus host (GVH) reaction was not impaired.
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M3 - Article
C2 - 6933896
AN - SCOPUS:0019260884
VL - 4
SP - 163
EP - 165
JO - Archives of toxicology. Supplement. Archiv fur Toxikologie. Supplement
JF - Archives of toxicology. Supplement. Archiv fur Toxikologie. Supplement
SN - 0171-9750
ER -