The effect of acute administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on humoral antibody production and cell-mediated activities in mice.

A. Vecchi, A. Mantovani, M. Sironi, W. Luini, F. Spreafico, S. Garattini

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of single doses of TCDD (1.2, 6 or 30 gamma/kg) on several immune parameters has been investigated in young adult C57B1/6 mice. TCDD profoundly suppressed the primary and secondary humoral response to T-dependent (sheep erythrocytes, SRBC) and T-independent (Type III pneumococcal polysaccharide, S III) antigens. In vitro lymphoproliferative responses to Concanavallin A (Con A) and bacterial lypopolysaccharide (LPS), and macrophage and natural killer (NK) cell-mediated cytotoxicity were not significantly affected per unit number of lymphoid cells. Moreover, the ability of splenocytes from TCDD treated animals to mediate a graft versus host (GVH) reaction was not impaired.

Original languageEnglish
Pages (from-to)163-165
Number of pages3
JournalArchives of toxicology. Supplement. Archiv fur Toxikologie. Supplement
Volume4
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Medicine(all)

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