L'effetto della stimolazione alpha 1-adrenergica del miocardio dipende dalle azioni opposte dei due sottotipi recettoriali.

Translated title of the contribution: The effect of alpha 1-adrenergic stimulation of the myocardium depends on the opposite actions of 2 receptor subtypes

G. Gambassi, M. C. Capogrossi

Research output: Contribution to journalArticlepeer-review

Abstract

Two different myocardial alpha 1-adrenergic receptor subtypes have been recently described. Since their functional role is still unknown we examined the effect of alpha 1A and alpha 1B on contractile properties, cell Ca2+ homeostasis and myofilament sensitivity to Ca2+ in indo-1 loaded ventricular myocytes. Non selective alpha 1-adrenergic stimulation increases twitch amplitude, systolic Ca2+ and myofilament sensitivity. Same effects but amplified are associated with alpha 1A-receptors stimulation. In contrast, alpha 1B-receptors stimulation decreases twitch amplitude and systolic Ca2+ below control value. Myocardial alpha 1-adrenergic stimulation results from the opposite actions of the 2 subtypes.

Translated title of the contributionThe effect of alpha 1-adrenergic stimulation of the myocardium depends on the opposite actions of 2 receptor subtypes
Original languageItalian
Pages (from-to)565-567
Number of pages3
JournalCardiologia
Volume37
Issue number8
Publication statusPublished - Aug 1992

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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