The effect of apolipoprotein polymorphism on brain in mild cognitive impairment: A voxel-based morphometric study

Corina Pennanen, Cristina Testa, Marina Boccardi, Mikko P. Laakso, Merja Hallikainen, Eeva Liisa Helkala, Tuomo Hänninen, Miia Kivipelto, Mervi Könönen, Aulikki Nissinen, Susanna Tervo, Matti Vanhanen, Ritva Vanninen, Giovani B. Frisoni, Hilkka Soininen

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the effect of apolipoprotein E (ApoE) on the whole brain in 51 individuals with mild cognitive impairment using voxel-based morphometry. Between cases heterozygous for the ApoE ε4 (n = 15) and those who were ApoE ε4 noncarriers (n = 28), only the right parahippocampal gyrus, with the entorhinal cortex included, reached the level of statistical significance. In cases homozygous for the ε4 allele (n = 8) versus noncarriers, the greatest atrophy was located in the right amygdala followed by the right parahippocampal gyrus, the left amygdala and the left medial dorsal thalamic nucleus.

Original languageEnglish
Pages (from-to)60-66
Number of pages7
JournalDementia and Geriatric Cognitive Disorders
Volume22
Issue number1
DOIs
Publication statusPublished - Jun 2006

Keywords

  • Alzheimer's disease
  • Amygdala
  • Apolipoprotein E
  • Entorhinal cortex
  • Hippocampus
  • Magnetic resonance imaging
  • Mild cognitive impairment
  • Thalamus
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology

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