The effect of astaxanthin on the aging rat brain: Gender-related differences in modulating inflammation

Marta Balietti, Stefano R. Giannubilo, Belinda Giorgetti, Moreno Solazzi, Angelo Turi, Tiziana Casoli, Andrea Ciavattini, Patrizia Fattoretti

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

BACKGROUND: Astaxanthin (Ax) is a ketocarotenoid of the xanthophyll family with activities such as antioxidation, preservation of the integrity of cell membranes and protection of the redox state and functional integrity of mitochondria. The aim of this study was to investigate potential gender-related differences in the effect of Ax on the aging rat brain. RESULTS: In females, interleukin 1 beta (IL1β) was significantly lower in treated rats in both cerebral areas, and in the cerebellum, treated animals also had significantly higher IL10. In males, no differences were found in the cerebellum, but in the hippocampus, IL1β and IL10 were significantly higher in treated rats. CONCLUSION: These are the first results to show gender-related differences in the effect of Ax on the aging brain, emphasizing the necessity to carefully analyze female and male peculiarities when the anti-aging potentialities of this ketocarotenoid are evaluated. The observations lead to the hypothesis that Ax exerts different anti-inflammatory effects in female and male brains.

Original languageEnglish
Pages (from-to)615-618
Number of pages4
JournalJournal of the Science of Food and Agriculture
Volume96
Issue number2
DOIs
Publication statusPublished - Jan 30 2016

Fingerprint

astaxanthin
inflammation
Inflammation
brain
gender
rats
interleukin-1
Brain
cerebellum
Interleukin-1beta
Interleukin-10
Cerebellum
Xanthophylls
Cytoprotection
hippocampus
anti-inflammatory activity
lutein
Oxidation-Reduction
cell membranes
Hippocampus

Keywords

  • Aging
  • Astaxanthin
  • Brain
  • Gender
  • Inflammation

ASJC Scopus subject areas

  • Agronomy and Crop Science
  • Food Science
  • Nutrition and Dietetics
  • Biotechnology

Cite this

The effect of astaxanthin on the aging rat brain : Gender-related differences in modulating inflammation. / Balietti, Marta; Giannubilo, Stefano R.; Giorgetti, Belinda; Solazzi, Moreno; Turi, Angelo; Casoli, Tiziana; Ciavattini, Andrea; Fattoretti, Patrizia.

In: Journal of the Science of Food and Agriculture, Vol. 96, No. 2, 30.01.2016, p. 615-618.

Research output: Contribution to journalArticle

Balietti, Marta ; Giannubilo, Stefano R. ; Giorgetti, Belinda ; Solazzi, Moreno ; Turi, Angelo ; Casoli, Tiziana ; Ciavattini, Andrea ; Fattoretti, Patrizia. / The effect of astaxanthin on the aging rat brain : Gender-related differences in modulating inflammation. In: Journal of the Science of Food and Agriculture. 2016 ; Vol. 96, No. 2. pp. 615-618.
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