The effect of celiprolol on the blood lipid profile in hypertensive patients with high cholesterol levels

Roberto Fogari, Annalisa Zoppi, Franco Tettamanti, Giandomenico Malamani, Carlo Pasotti

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to compare the effects of chronic antihypertensive therapy with either celiprolol or atenolol on plasma lipids in patients with hypercholesterolemia. Forty-six patients with essential hypertension and a total cholesterol (TC) concentration > 220 mg/dl were studied. After 1 month on placebo, patients were stratified into five classes on the basis of their plasma TC levels and then randomized to receive atenolol 100 mg/day or celiprolol 400 mg/day for 1 year. Blood pressure (BP), heart rate (HR), and blood samples for evaluation of TC, HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), and triglycerides (TG) were taken before and after the placebo period, and every 6 months from the beginning of the active treatment. Celiprolol and atenolol caused similar reduction in BP. Both atenolol and celiprolol decreased TC. Atenolol significantly reduced HDL-C, while celiprolol increased it (p

Original languageEnglish
Pages (from-to)1287-1290
Number of pages4
JournalCardiovascular Drugs and Therapy
Volume4
Issue number6 Supplement
DOIs
Publication statusPublished - Jan 1991

Keywords

  • beta blockers
  • celiprolol
  • hypercholesterolemia
  • hypertension
  • lipids

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Cardiology and Cardiovascular Medicine

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