The effect of celiprolol on the blood lipid profile in hypertensive patients with high cholesterol levels

Roberto Fogari, Annalisa Zoppi, Franco Tettamanti, Giandomenico Malamani, Carlo Pasotti

Research output: Contribution to journalArticle

Abstract

The aim of this study was to compare the effects of chronic antihypertensive therapy with either celiprolol or atenolol on plasma lipids in patients with hypercholesterolemia. Forty-six patients with essential hypertension and a total cholesterol (TC) concentration > 220 mg/dl were studied. After 1 month on placebo, patients were stratified into five classes on the basis of their plasma TC levels and then randomized to receive atenolol 100 mg/day or celiprolol 400 mg/day for 1 year. Blood pressure (BP), heart rate (HR), and blood samples for evaluation of TC, HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), and triglycerides (TG) were taken before and after the placebo period, and every 6 months from the beginning of the active treatment. Celiprolol and atenolol caused similar reduction in BP. Both atenolol and celiprolol decreased TC. Atenolol significantly reduced HDL-C, while celiprolol increased it (p

Original languageEnglish
Pages (from-to)1287-1290
Number of pages4
JournalCardiovascular Drugs and Therapy
Volume4
Issue number6 Supplement
DOIs
Publication statusPublished - Jan 1991

Keywords

  • beta blockers
  • celiprolol
  • hypercholesterolemia
  • hypertension
  • lipids

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Cardiology and Cardiovascular Medicine

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