The effect of certain antiplatelet drugs on in vitro malonylaldehyde (MDA) production

F. Fabris; A. Casonato; L. De Marco; A. Girolami

The effect of certain antiplatelet drugs on in vitro malonylaldehyde (MDA) production

F. Fabris, A. Casonato, L. De Marco, A. Girolami

Centro di Riferimento Oncologico

Research output: Contribution to journal › Article › peer-review

Abstract

Several antiaggregating agents were tested with regard to their effect on platelet malonylaldehyde (MDA) production which seems to be a good marker of prostaglandin metabolism. Non-steroidal antiinflammatory compounds, namely acetylsalicylic acid (ASA), ditazole and sulfinpyrazone, showed a sure, statistically significant inhibitory effect on MDA production while theophylline, adenosine and α-blocking agent nycergoline did not. Dipyridamole on the contrary, was demonstrated to have a mild but still statistically significant effect on the inhibition of platelet MDA production.

Original language	English
Pages (from-to)	981-983
Number of pages	3
Journal	Arzneimittel-Forschung/Drug Research
Volume	29
Issue number	7
Publication status	Published - 1979

ASJC Scopus subject areas

Chemistry(all)
Organic Chemistry
Drug Discovery
Pharmacology

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title = "The effect of certain antiplatelet drugs on in vitro malonylaldehyde (MDA) production",

abstract = "Several antiaggregating agents were tested with regard to their effect on platelet malonylaldehyde (MDA) production which seems to be a good marker of prostaglandin metabolism. Non-steroidal antiinflammatory compounds, namely acetylsalicylic acid (ASA), ditazole and sulfinpyrazone, showed a sure, statistically significant inhibitory effect on MDA production while theophylline, adenosine and α-blocking agent nycergoline did not. Dipyridamole on the contrary, was demonstrated to have a mild but still statistically significant effect on the inhibition of platelet MDA production.",

author = "F. Fabris and A. Casonato and {De Marco}, L. and A. Girolami",

year = "1979",

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AU - Casonato, A.

AU - De Marco, L.

AU - Girolami, A.

PY - 1979

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N2 - Several antiaggregating agents were tested with regard to their effect on platelet malonylaldehyde (MDA) production which seems to be a good marker of prostaglandin metabolism. Non-steroidal antiinflammatory compounds, namely acetylsalicylic acid (ASA), ditazole and sulfinpyrazone, showed a sure, statistically significant inhibitory effect on MDA production while theophylline, adenosine and α-blocking agent nycergoline did not. Dipyridamole on the contrary, was demonstrated to have a mild but still statistically significant effect on the inhibition of platelet MDA production.

AB - Several antiaggregating agents were tested with regard to their effect on platelet malonylaldehyde (MDA) production which seems to be a good marker of prostaglandin metabolism. Non-steroidal antiinflammatory compounds, namely acetylsalicylic acid (ASA), ditazole and sulfinpyrazone, showed a sure, statistically significant inhibitory effect on MDA production while theophylline, adenosine and α-blocking agent nycergoline did not. Dipyridamole on the contrary, was demonstrated to have a mild but still statistically significant effect on the inhibition of platelet MDA production.

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