The effect of certain antiplatelet drugs on in vitro malonylaldehyde (MDA) production

F. Fabris, A. Casonato, L. De Marco, A. Girolami

Research output: Contribution to journalArticle

Abstract

Several antiaggregating agents were tested with regard to their effect on platelet malonylaldehyde (MDA) production which seems to be a good marker of prostaglandin metabolism. Non-steroidal antiinflammatory compounds, namely acetylsalicylic acid (ASA), ditazole and sulfinpyrazone, showed a sure, statistically significant inhibitory effect on MDA production while theophylline, adenosine and α-blocking agent nycergoline did not. Dipyridamole on the contrary, was demonstrated to have a mild but still statistically significant effect on the inhibition of platelet MDA production.

Original languageEnglish
Pages (from-to)981-983
Number of pages3
JournalArzneimittel-Forschung/Drug Research
Volume29
Issue number7
Publication statusPublished - 1979

    Fingerprint

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Fabris, F., Casonato, A., De Marco, L., & Girolami, A. (1979). The effect of certain antiplatelet drugs on in vitro malonylaldehyde (MDA) production. Arzneimittel-Forschung/Drug Research, 29(7), 981-983.