Abstract
Several antiaggregating agents were tested with regard to their effect on platelet malonylaldehyde (MDA) production which seems to be a good marker of prostaglandin metabolism. Non-steroidal antiinflammatory compounds, namely acetylsalicylic acid (ASA), ditazole and sulfinpyrazone, showed a sure, statistically significant inhibitory effect on MDA production while theophylline, adenosine and α-blocking agent nycergoline did not. Dipyridamole on the contrary, was demonstrated to have a mild but still statistically significant effect on the inhibition of platelet MDA production.
| Original language | English |
|---|---|
| Pages (from-to) | 981-983 |
| Number of pages | 3 |
| Journal | Arzneimittel-Forschung/Drug Research |
| Volume | 29 |
| Issue number | 7 |
| Publication status | Published - 1979 |
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ASJC Scopus subject areas
- Chemistry(all)
- Organic Chemistry
- Drug Discovery
- Pharmacology
Cite this
The effect of certain antiplatelet drugs on in vitro malonylaldehyde (MDA) production. / Fabris, F.; Casonato, A.; De Marco, L.; Girolami, A.
In: Arzneimittel-Forschung/Drug Research, Vol. 29, No. 7, 1979, p. 981-983.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of certain antiplatelet drugs on in vitro malonylaldehyde (MDA) production
AU - Fabris, F.
AU - Casonato, A.
AU - De Marco, L.
AU - Girolami, A.
PY - 1979
Y1 - 1979
N2 - Several antiaggregating agents were tested with regard to their effect on platelet malonylaldehyde (MDA) production which seems to be a good marker of prostaglandin metabolism. Non-steroidal antiinflammatory compounds, namely acetylsalicylic acid (ASA), ditazole and sulfinpyrazone, showed a sure, statistically significant inhibitory effect on MDA production while theophylline, adenosine and α-blocking agent nycergoline did not. Dipyridamole on the contrary, was demonstrated to have a mild but still statistically significant effect on the inhibition of platelet MDA production.
AB - Several antiaggregating agents were tested with regard to their effect on platelet malonylaldehyde (MDA) production which seems to be a good marker of prostaglandin metabolism. Non-steroidal antiinflammatory compounds, namely acetylsalicylic acid (ASA), ditazole and sulfinpyrazone, showed a sure, statistically significant inhibitory effect on MDA production while theophylline, adenosine and α-blocking agent nycergoline did not. Dipyridamole on the contrary, was demonstrated to have a mild but still statistically significant effect on the inhibition of platelet MDA production.
UR - http://www.scopus.com/inward/record.url?scp=0018745417&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018745417&partnerID=8YFLogxK
M3 - Article
VL - 29
SP - 981
EP - 983
JO - Arzneimittel-Forschung/Drug Research
JF - Arzneimittel-Forschung/Drug Research
SN - 0004-4172
IS - 7
ER -