The effect of certain antiplatelet drugs on in vitro malonylaldehyde (MDA) production

F. Fabris, A. Casonato, L. De Marco, A. Girolami

Research output: Contribution to journalArticlepeer-review

Abstract

Several antiaggregating agents were tested with regard to their effect on platelet malonylaldehyde (MDA) production which seems to be a good marker of prostaglandin metabolism. Non-steroidal antiinflammatory compounds, namely acetylsalicylic acid (ASA), ditazole and sulfinpyrazone, showed a sure, statistically significant inhibitory effect on MDA production while theophylline, adenosine and α-blocking agent nycergoline did not. Dipyridamole on the contrary, was demonstrated to have a mild but still statistically significant effect on the inhibition of platelet MDA production.

Original languageEnglish
Pages (from-to)981-983
Number of pages3
JournalArzneimittel-Forschung/Drug Research
Volume29
Issue number7
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

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