Abstract
Several antiaggregating agents were tested with regard to their effect on platelet malonylaldehyde (MDA) production which seems to be a good marker of prostaglandin metabolism. Non-steroidal antiinflammatory compounds, namely acetylsalicylic acid (ASA), ditazole and sulfinpyrazone, showed a sure, statistically significant inhibitory effect on MDA production while theophylline, adenosine and α-blocking agent nycergoline did not. Dipyridamole on the contrary, was demonstrated to have a mild but still statistically significant effect on the inhibition of platelet MDA production.
| Original language | English |
|---|---|
| Pages (from-to) | 981-983 |
| Number of pages | 3 |
| Journal | Arzneimittel-Forschung/Drug Research |
| Volume | 29 |
| Issue number | 7 |
| Publication status | Published - 1979 |
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ASJC Scopus subject areas
- Chemistry(all)
- Organic Chemistry
- Drug Discovery
- Pharmacology
Cite this
Fabris, F., Casonato, A., De Marco, L., & Girolami, A. (1979). The effect of certain antiplatelet drugs on in vitro malonylaldehyde (MDA) production. Arzneimittel-Forschung/Drug Research, 29(7), 981-983.