The effect of chronic physical exercise on succinic dehydrogenase activity in the heart muscle of old rats

Marta Balietti, Patrizia Fattoretti, Monika Skalicky, Andrus Viidik, Belinda Giorgetti, Yessica Grossi, Carlo Bertoni-Freddari

Research output: Contribution to journalArticle

Abstract

Succinic dehydrogenase (SDH) activity, preferentially evidenced by cytochemical methods, has been measured by computer-assisted morphometry in the heart muscle of old sedentary and age-matched animals chronically undergone physical exercise (20 min, twice a day, 5 days a week). The area of the SDH-positive mitochondria (MA) and the overall area of the cytochemical precipitates due to SDH activity (PA) were semiautomatically measured and the ratios PA/MA as well as MA/overall myocardial tissue area analysed (MA/TA) were the parameters taken into account. No significant difference was found between the two groups investigated as regards PA/MA, whereas the MA/TA value is significantly increased in the animals undergone physical training. The present findings document that chronic physical exercise significantly increases the overall mitochondrial area involved in energy provision in the old myocardial tissue. Considering that myocardial function highly relies on mitochondrial metabolism, our results support a beneficial effect of chronic physical exercise on the old heart muscle.

Original languageEnglish
Pages (from-to)95-100
Number of pages6
JournalBiogerontology
Volume6
Issue number2
DOIs
Publication statusPublished - Mar 2005

Keywords

  • Heart aging
  • Myocyte
  • Physical exercise in aging
  • SDH activity
  • Succinic dehydrogenase

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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