The effect of chronically occluded coronary artery recanalisation on baroreflex sensitivity and left ventricular systolic function

Ludmiła Daniłowicz-Szymanowicz, Gian Domenico Pinna, Karolina Dorniak, Grzegorz Mincewicz, Paweł Zagozdzon, Waldemar Dorniak, Justyna Suchecka, Grzegorz Raczak

Research output: Contribution to journalArticle

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Abstract

Background: Recanalisation of chronic total occlusion (CTO) of a coronary artery can be reflected by improvements in various clinical parameters. Revealing increased parasympathetic activity would constitute an additional argument for performing this procedure. Aim: To assess the effect of CTO recanalisation on baroreflex sensitivity (BRS) and left ventricular ejection fraction (LVEF) in stable symptomatic patients with coronary artery disease. Methods: BRS (spectral analysis, transfer function, Blackman-Tukey algorithm, 0.03 Hz bandwidth Parzen window) and LVEF (echocardiography, Simpson's method) were analysed in 23 patients: one day (R1) before, one day (R2) after, and three months (R3) after CTO recanalisation. Patients were divided into two groups: those with depressed (≤ 3 ms/mm Hg) or preserved (> 3 ms/mm Hg) BRS. Results: Significant BRS changes were observed in the study group compared to baseline values (p = 0.016). In the patients with a depressed reflex, BRS in R2 was similar to R1 and almost doubled in R3 (p = 0.018). In the patients with a preserved reflex, BRS significantly decreased in R2 (p = 0.024) and returned to the baseline value in R3. The behaviour of LVEF was homogenous in the groups, showing an increase from R1 to R3. Conclusions: The improvement in autonomic nervous system activity after successful CTO recanalisation is reflected by an increase in BRS, and the changes are dependent on the baseline value of the measurement: patients with a depressed BRS before recanalisation present a greater BRS improvement than patients with a preserved BRS. The CTO recanalisation leads to the improvement of LVEF in both groups.

Original languageEnglish
Pages (from-to)438-445
Number of pages8
JournalKardiologia polska.
Volume72
Issue number5
DOIs
Publication statusPublished - May 16 2014

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Baroreflex
Left Ventricular Function
Coronary Vessels
Stroke Volume
Reflex
Autonomic Nervous System
Echocardiography
Coronary Artery Disease

Keywords

  • Baroreflex sensitivity
  • Ejection fraction
  • Recanalisation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The effect of chronically occluded coronary artery recanalisation on baroreflex sensitivity and left ventricular systolic function. / Daniłowicz-Szymanowicz, Ludmiła; Pinna, Gian Domenico; Dorniak, Karolina; Mincewicz, Grzegorz; Zagozdzon, Paweł; Dorniak, Waldemar; Suchecka, Justyna; Raczak, Grzegorz.

In: Kardiologia polska., Vol. 72, No. 5, 16.05.2014, p. 438-445.

Research output: Contribution to journalArticle

Daniłowicz-Szymanowicz, L, Pinna, GD, Dorniak, K, Mincewicz, G, Zagozdzon, P, Dorniak, W, Suchecka, J & Raczak, G 2014, 'The effect of chronically occluded coronary artery recanalisation on baroreflex sensitivity and left ventricular systolic function', Kardiologia polska., vol. 72, no. 5, pp. 438-445. https://doi.org/10.5603/KP.a2013.0356
Daniłowicz-Szymanowicz, Ludmiła ; Pinna, Gian Domenico ; Dorniak, Karolina ; Mincewicz, Grzegorz ; Zagozdzon, Paweł ; Dorniak, Waldemar ; Suchecka, Justyna ; Raczak, Grzegorz. / The effect of chronically occluded coronary artery recanalisation on baroreflex sensitivity and left ventricular systolic function. In: Kardiologia polska. 2014 ; Vol. 72, No. 5. pp. 438-445.
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AU - Daniłowicz-Szymanowicz, Ludmiła

AU - Pinna, Gian Domenico

AU - Dorniak, Karolina

AU - Mincewicz, Grzegorz

AU - Zagozdzon, Paweł

AU - Dorniak, Waldemar

AU - Suchecka, Justyna

AU - Raczak, Grzegorz

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