Abstract
Background: Recanalisation of chronic total occlusion (CTO) of a coronary artery can be reflected by improvements in various clinical parameters. Revealing increased parasympathetic activity would constitute an additional argument for performing this procedure. Aim: To assess the effect of CTO recanalisation on baroreflex sensitivity (BRS) and left ventricular ejection fraction (LVEF) in stable symptomatic patients with coronary artery disease. Methods: BRS (spectral analysis, transfer function, Blackman-Tukey algorithm, 0.03 Hz bandwidth Parzen window) and LVEF (echocardiography, Simpson's method) were analysed in 23 patients: one day (R1) before, one day (R2) after, and three months (R3) after CTO recanalisation. Patients were divided into two groups: those with depressed (≤ 3 ms/mm Hg) or preserved (> 3 ms/mm Hg) BRS. Results: Significant BRS changes were observed in the study group compared to baseline values (p = 0.016). In the patients with a depressed reflex, BRS in R2 was similar to R1 and almost doubled in R3 (p = 0.018). In the patients with a preserved reflex, BRS significantly decreased in R2 (p = 0.024) and returned to the baseline value in R3. The behaviour of LVEF was homogenous in the groups, showing an increase from R1 to R3. Conclusions: The improvement in autonomic nervous system activity after successful CTO recanalisation is reflected by an increase in BRS, and the changes are dependent on the baseline value of the measurement: patients with a depressed BRS before recanalisation present a greater BRS improvement than patients with a preserved BRS. The CTO recanalisation leads to the improvement of LVEF in both groups.
| Original language | English |
|---|---|
| Pages (from-to) | 438-445 |
| Number of pages | 8 |
| Journal | Kardiologia polska. |
| Volume | 72 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 16 2014 |
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Keywords
- Baroreflex sensitivity
- Ejection fraction
- Recanalisation
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
The effect of chronically occluded coronary artery recanalisation on baroreflex sensitivity and left ventricular systolic function. / Daniłowicz-Szymanowicz, Ludmiła; Pinna, Gian Domenico; Dorniak, Karolina; Mincewicz, Grzegorz; Zagozdzon, Paweł; Dorniak, Waldemar; Suchecka, Justyna; Raczak, Grzegorz.
In: Kardiologia polska., Vol. 72, No. 5, 16.05.2014, p. 438-445.Research output: Contribution to journal › Article
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TY - JOUR
T1 - The effect of chronically occluded coronary artery recanalisation on baroreflex sensitivity and left ventricular systolic function
AU - Daniłowicz-Szymanowicz, Ludmiła
AU - Pinna, Gian Domenico
AU - Dorniak, Karolina
AU - Mincewicz, Grzegorz
AU - Zagozdzon, Paweł
AU - Dorniak, Waldemar
AU - Suchecka, Justyna
AU - Raczak, Grzegorz
PY - 2014/5/16
Y1 - 2014/5/16
N2 - Background: Recanalisation of chronic total occlusion (CTO) of a coronary artery can be reflected by improvements in various clinical parameters. Revealing increased parasympathetic activity would constitute an additional argument for performing this procedure. Aim: To assess the effect of CTO recanalisation on baroreflex sensitivity (BRS) and left ventricular ejection fraction (LVEF) in stable symptomatic patients with coronary artery disease. Methods: BRS (spectral analysis, transfer function, Blackman-Tukey algorithm, 0.03 Hz bandwidth Parzen window) and LVEF (echocardiography, Simpson's method) were analysed in 23 patients: one day (R1) before, one day (R2) after, and three months (R3) after CTO recanalisation. Patients were divided into two groups: those with depressed (≤ 3 ms/mm Hg) or preserved (> 3 ms/mm Hg) BRS. Results: Significant BRS changes were observed in the study group compared to baseline values (p = 0.016). In the patients with a depressed reflex, BRS in R2 was similar to R1 and almost doubled in R3 (p = 0.018). In the patients with a preserved reflex, BRS significantly decreased in R2 (p = 0.024) and returned to the baseline value in R3. The behaviour of LVEF was homogenous in the groups, showing an increase from R1 to R3. Conclusions: The improvement in autonomic nervous system activity after successful CTO recanalisation is reflected by an increase in BRS, and the changes are dependent on the baseline value of the measurement: patients with a depressed BRS before recanalisation present a greater BRS improvement than patients with a preserved BRS. The CTO recanalisation leads to the improvement of LVEF in both groups.
AB - Background: Recanalisation of chronic total occlusion (CTO) of a coronary artery can be reflected by improvements in various clinical parameters. Revealing increased parasympathetic activity would constitute an additional argument for performing this procedure. Aim: To assess the effect of CTO recanalisation on baroreflex sensitivity (BRS) and left ventricular ejection fraction (LVEF) in stable symptomatic patients with coronary artery disease. Methods: BRS (spectral analysis, transfer function, Blackman-Tukey algorithm, 0.03 Hz bandwidth Parzen window) and LVEF (echocardiography, Simpson's method) were analysed in 23 patients: one day (R1) before, one day (R2) after, and three months (R3) after CTO recanalisation. Patients were divided into two groups: those with depressed (≤ 3 ms/mm Hg) or preserved (> 3 ms/mm Hg) BRS. Results: Significant BRS changes were observed in the study group compared to baseline values (p = 0.016). In the patients with a depressed reflex, BRS in R2 was similar to R1 and almost doubled in R3 (p = 0.018). In the patients with a preserved reflex, BRS significantly decreased in R2 (p = 0.024) and returned to the baseline value in R3. The behaviour of LVEF was homogenous in the groups, showing an increase from R1 to R3. Conclusions: The improvement in autonomic nervous system activity after successful CTO recanalisation is reflected by an increase in BRS, and the changes are dependent on the baseline value of the measurement: patients with a depressed BRS before recanalisation present a greater BRS improvement than patients with a preserved BRS. The CTO recanalisation leads to the improvement of LVEF in both groups.
KW - Baroreflex sensitivity
KW - Ejection fraction
KW - Recanalisation
UR - http://www.scopus.com/inward/record.url?scp=84901462537&partnerID=8YFLogxK
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U2 - 10.5603/KP.a2013.0356
DO - 10.5603/KP.a2013.0356
M3 - Article
VL - 72
SP - 438
EP - 445
JO - Kardiologia Polska
JF - Kardiologia Polska
SN - 0022-9032
IS - 5
ER -