The effect of CYP, GST, and SULT polymorphisms and their interaction with smoking on the risk of hepatocellular carcinoma

Stefania Boccia, Luca Miele, Nikola Panic, Federica Turati, Dario Arzani, Consuelo Cefalo, Rosarita Amore, Milutin Bulajic, Maurizio Pompili, Gianlodovico Rapaccini, Antonio Gasbarrini, Carlo La Vecchia, Antonio Grieco

Research output: Contribution to journalArticlepeer-review

Abstract

Aim.The aim of our study was to assess whether selected single nucleotide polymorphisms of CYP1A1 and 2E1,GSTM1,GSTT1,and SULT1A1 influence susceptibility towards HCC,considering their interaction with cigarette smoking.Methods.We recruited HCC cases and controls among patients admitted to the hospital "Agostino Gemelli,"from January 2005 until July 2010.Odds ratios (OR) of HCC were derived from unconditional multiple logistic regression.Gene-gene and gene-smoking interaction were quantified by computing the attributable proportion (AP) due to biological interaction.Results.The presence of any CYP2E1 5B variant allele (OR:0.23;95% CI:0.06-0.71) and CYP2E1 6 variant allele (OR:0.08;95% CI:0.01-0.33) was inversely related to HCC.There was a borderline increased risk among carriers of combined CYP1A1 2A and SULT1A1 variant alleles (OR:1.67;95% CI:0.97-3.24). A significant biological interaction was observed between GSTT1 and smoking (AP = 0.48; 95% CI: 0.001-0.815), with an OR of 3.13 (95% CI: 1.69-5.82), and borderline significant interaction was observed for SULT1A1 and smoking (AP = 0.36; 95% CI: -0.021-0.747), with an OR of 3.05 (95% CI: 1.73-5.40). Conclusion. CYP2E1 5B and CYP2E1 6 polymorphisms have a favourable effect on the development of HCC, while polymorphisms of GSTT1 and SULT1A1 might play role in increasing the susceptibility among smokers.

Original languageEnglish
Article number179867
JournalBioMed Research International
Volume2015
DOIs
Publication statusPublished - Jan 14 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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