The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing-remitting multiple sclerosis

Giovanni Frisullo, Massimiliano Mirabella, Francesco Angelucci, Marcella Caggiula, Roberta Morosetti, Cristina Sancricca, Agata Katia Patanella, Viviana Nociti, Raffaele Iorio, Assunta Bianco, Valentina Tomassini, Carlo Pozzilli, Pietro Attilio Tonali, Giuseppe Matarese, Anna Paola Batocchi

Research output: Contribution to journalArticle

Abstract

In this study we observed higher serum leptin levels in relapsing-remitting multiple sclerosis (RRMS) patients during remission than in controls. The expression of leptin receptor (ObR) was higher in CD8+ T cells and monocytes from RRMS patients in relapse than in patients in remission and in controls. Relapsing patients showed high levels of pSTAT3 and low expression of SOCS3 and leptin administration induced an up-regulation of pSTAT3 only in monocytes from patients in relapse. Our data suggest that ObR may be involved in the development of clinical relapses in RRMS patients and suggest a rationale for potential targeting of the leptin axis during MS.

Original languageEnglish
Pages (from-to)174-183
Number of pages10
JournalJournal of Neuroimmunology
Volume192
Issue number1-2
DOIs
Publication statusPublished - Dec 2007

Keywords

  • Leptin
  • Multiple sclerosis
  • SOCS3
  • STAT3
  • Transcription factors

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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  • Cite this

    Frisullo, G., Mirabella, M., Angelucci, F., Caggiula, M., Morosetti, R., Sancricca, C., Patanella, A. K., Nociti, V., Iorio, R., Bianco, A., Tomassini, V., Pozzilli, C., Tonali, P. A., Matarese, G., & Batocchi, A. P. (2007). The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing-remitting multiple sclerosis. Journal of Neuroimmunology, 192(1-2), 174-183. https://doi.org/10.1016/j.jneuroim.2007.08.008