The effect of extent of caval resection in the treatment of inferior vena cava leiomyosarcoma

Andrea Mingoli, Paolo Sapienza, Antonino Cavallaro, Luca Di Marzo, Claudia Burchi, Diana Giannarelli, Richard J. Feldhaus

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Abstract

Background. A wide and complete surgical resection is the principle modality of therapy in the management of retroperitoneal sarcomas. It is current opinion that, also for inferior vena cava (IVC) leiomyosarcomas, an extended resection of either retroperitoneal tissue and vena cava should be performed. The aim of the study was to investigate the influence of the venous extent of resection of local recurrence and long-term outcome. Methods. Up to August 1994, 218 patients were enrolled into The International Registry of Inferior Vena Cava (IVC) Leiomyosarcomas. For the purpose of this study we considered 120 patients who underwent a radical resection of the IVC tumor (i.e. removal of all gross disease with microscopic tumor-free margins and no evidence of distant metastases). Resection included an IVC rim in 53 patients and an IVC segment in 67. Results. There were 3 (2.5%) early postoperative deaths and 7 (5.8%) major complications. Postoperative deep venous thrombosis of the lower limbs was diagnosed in 21 (17.5%) patients and was treated by anticoagulant therapy and/or elastic stocking without long-term sequelae. Overall, tumor recurrence was observed in 67 (57.3%) patients at a mean follow-up of 32 ± 4 months. Seven, 13 and 4 patients who underwent caval wall resection and 9, 29 and 5 patients submitted to a caval segmental resection had either local recurrences, distant metastases or local and distant metastases (p = NS). Survival rates of the two groups were 55% and 37% at 5-year and 42% and 23% at 10-year, respectively (p = NS). Conclusion. An extended venous resection in IVC leiomyosarcoma does not influence local recurrence rate nor long-term outcome.

Original languageEnglish
Pages (from-to)3877-3881
Number of pages5
JournalAnticancer Research
Volume17
Issue number5 B
Publication statusPublished - Sep 1997

Fingerprint

Venae Cavae
Leiomyosarcoma
Inferior Vena Cava
Recurrence
Neoplasm Metastasis
Therapeutics
Compression Stockings
Venous Thrombosis
Sarcoma
Anticoagulants
Registries
Lower Extremity
Neoplasms
Survival Rate

Keywords

  • Vena cava leiomyosarcoma
  • Venous resection

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Mingoli, A., Sapienza, P., Cavallaro, A., Di Marzo, L., Burchi, C., Giannarelli, D., & Feldhaus, R. J. (1997). The effect of extent of caval resection in the treatment of inferior vena cava leiomyosarcoma. Anticancer Research, 17(5 B), 3877-3881.

The effect of extent of caval resection in the treatment of inferior vena cava leiomyosarcoma. / Mingoli, Andrea; Sapienza, Paolo; Cavallaro, Antonino; Di Marzo, Luca; Burchi, Claudia; Giannarelli, Diana; Feldhaus, Richard J.

In: Anticancer Research, Vol. 17, No. 5 B, 09.1997, p. 3877-3881.

Research output: Contribution to journalArticle

Mingoli, A, Sapienza, P, Cavallaro, A, Di Marzo, L, Burchi, C, Giannarelli, D & Feldhaus, RJ 1997, 'The effect of extent of caval resection in the treatment of inferior vena cava leiomyosarcoma', Anticancer Research, vol. 17, no. 5 B, pp. 3877-3881.
Mingoli A, Sapienza P, Cavallaro A, Di Marzo L, Burchi C, Giannarelli D et al. The effect of extent of caval resection in the treatment of inferior vena cava leiomyosarcoma. Anticancer Research. 1997 Sep;17(5 B):3877-3881.
Mingoli, Andrea ; Sapienza, Paolo ; Cavallaro, Antonino ; Di Marzo, Luca ; Burchi, Claudia ; Giannarelli, Diana ; Feldhaus, Richard J. / The effect of extent of caval resection in the treatment of inferior vena cava leiomyosarcoma. In: Anticancer Research. 1997 ; Vol. 17, No. 5 B. pp. 3877-3881.
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abstract = "Background. A wide and complete surgical resection is the principle modality of therapy in the management of retroperitoneal sarcomas. It is current opinion that, also for inferior vena cava (IVC) leiomyosarcomas, an extended resection of either retroperitoneal tissue and vena cava should be performed. The aim of the study was to investigate the influence of the venous extent of resection of local recurrence and long-term outcome. Methods. Up to August 1994, 218 patients were enrolled into The International Registry of Inferior Vena Cava (IVC) Leiomyosarcomas. For the purpose of this study we considered 120 patients who underwent a radical resection of the IVC tumor (i.e. removal of all gross disease with microscopic tumor-free margins and no evidence of distant metastases). Resection included an IVC rim in 53 patients and an IVC segment in 67. Results. There were 3 (2.5{\%}) early postoperative deaths and 7 (5.8{\%}) major complications. Postoperative deep venous thrombosis of the lower limbs was diagnosed in 21 (17.5{\%}) patients and was treated by anticoagulant therapy and/or elastic stocking without long-term sequelae. Overall, tumor recurrence was observed in 67 (57.3{\%}) patients at a mean follow-up of 32 ± 4 months. Seven, 13 and 4 patients who underwent caval wall resection and 9, 29 and 5 patients submitted to a caval segmental resection had either local recurrences, distant metastases or local and distant metastases (p = NS). Survival rates of the two groups were 55{\%} and 37{\%} at 5-year and 42{\%} and 23{\%} at 10-year, respectively (p = NS). Conclusion. An extended venous resection in IVC leiomyosarcoma does not influence local recurrence rate nor long-term outcome.",
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AU - Mingoli, Andrea

AU - Sapienza, Paolo

AU - Cavallaro, Antonino

AU - Di Marzo, Luca

AU - Burchi, Claudia

AU - Giannarelli, Diana

AU - Feldhaus, Richard J.

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N2 - Background. A wide and complete surgical resection is the principle modality of therapy in the management of retroperitoneal sarcomas. It is current opinion that, also for inferior vena cava (IVC) leiomyosarcomas, an extended resection of either retroperitoneal tissue and vena cava should be performed. The aim of the study was to investigate the influence of the venous extent of resection of local recurrence and long-term outcome. Methods. Up to August 1994, 218 patients were enrolled into The International Registry of Inferior Vena Cava (IVC) Leiomyosarcomas. For the purpose of this study we considered 120 patients who underwent a radical resection of the IVC tumor (i.e. removal of all gross disease with microscopic tumor-free margins and no evidence of distant metastases). Resection included an IVC rim in 53 patients and an IVC segment in 67. Results. There were 3 (2.5%) early postoperative deaths and 7 (5.8%) major complications. Postoperative deep venous thrombosis of the lower limbs was diagnosed in 21 (17.5%) patients and was treated by anticoagulant therapy and/or elastic stocking without long-term sequelae. Overall, tumor recurrence was observed in 67 (57.3%) patients at a mean follow-up of 32 ± 4 months. Seven, 13 and 4 patients who underwent caval wall resection and 9, 29 and 5 patients submitted to a caval segmental resection had either local recurrences, distant metastases or local and distant metastases (p = NS). Survival rates of the two groups were 55% and 37% at 5-year and 42% and 23% at 10-year, respectively (p = NS). Conclusion. An extended venous resection in IVC leiomyosarcoma does not influence local recurrence rate nor long-term outcome.

AB - Background. A wide and complete surgical resection is the principle modality of therapy in the management of retroperitoneal sarcomas. It is current opinion that, also for inferior vena cava (IVC) leiomyosarcomas, an extended resection of either retroperitoneal tissue and vena cava should be performed. The aim of the study was to investigate the influence of the venous extent of resection of local recurrence and long-term outcome. Methods. Up to August 1994, 218 patients were enrolled into The International Registry of Inferior Vena Cava (IVC) Leiomyosarcomas. For the purpose of this study we considered 120 patients who underwent a radical resection of the IVC tumor (i.e. removal of all gross disease with microscopic tumor-free margins and no evidence of distant metastases). Resection included an IVC rim in 53 patients and an IVC segment in 67. Results. There were 3 (2.5%) early postoperative deaths and 7 (5.8%) major complications. Postoperative deep venous thrombosis of the lower limbs was diagnosed in 21 (17.5%) patients and was treated by anticoagulant therapy and/or elastic stocking without long-term sequelae. Overall, tumor recurrence was observed in 67 (57.3%) patients at a mean follow-up of 32 ± 4 months. Seven, 13 and 4 patients who underwent caval wall resection and 9, 29 and 5 patients submitted to a caval segmental resection had either local recurrences, distant metastases or local and distant metastases (p = NS). Survival rates of the two groups were 55% and 37% at 5-year and 42% and 23% at 10-year, respectively (p = NS). Conclusion. An extended venous resection in IVC leiomyosarcoma does not influence local recurrence rate nor long-term outcome.

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