The effect of external eye irradiation on choroidal circulation

E. Midena, T. Segato, M. Valenti, C. D. Angeli, E. Bertoja, S. Piermarocchi

Research output: Contribution to journalArticle

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Abstract

Background: The effect of external beam radiation therapy (teletherapy) on the choroidal circulation is poorly known. Eyes irradiated with teletherapy represent a good model to study, without confounding factors, the pathophysiologic and clinical aspects of radiation-induced chorioretinal damage. This study used fluorescein and indocyanine green choroidal angiography to investigate the late effects of external eye irradiation on the choroidal circulation. Methods: Fluorescein angiography and indocyanine green choroidal videoangiography were performed on patients with radiation retinopathy because of external eye irradiation for orbital and paranasal sinus malignancies. Patients were divided into two groups according to the treatment field (anterior unilateral or bilateral). Results: Indocyanine green angiograms showed areas of choriocapillaris hypoperfusion in all eyes- unilateral or bilateral irradiation-affected by radiation retinopathy. Late indocyanine green choroidal staining was found in five eyes (28%) of the patients who received unilateral anterior irradiation. In the same group, nine eyes (52%) had signs of choroidal precapillary occlusion and four eyes (23%) had rubeosis iridis without retinal neovascularization. One case of subfoveal choroidal neovascularization was documented in the bilateral irradiation group. Conclusions: Radiation side effects are not limited to the retinal vessels but also involve choroidal circulation. The damage to the choroid is primarily vascular, and its clinical aspects depend on the treatment fields. Anterior irradiation may be a critical factor for the appearance of unusual rubeosis iridis and neovascular glaucoma.

Original languageEnglish
Pages (from-to)1651-1660
Number of pages10
JournalOphthalmology
Volume103
Issue number10
Publication statusPublished - 1996

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Indocyanine Green
Radiation
Angiography
Retinal Neovascularization
Neovascular Glaucoma
Retinal Vessels
Choroidal Neovascularization
Choroid
Fluorescein Angiography
Paranasal Sinuses
Radiation Effects
Fluorescein
Blood Vessels
Staining and Labeling
Therapeutics
Neoplasms

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Midena, E., Segato, T., Valenti, M., Angeli, C. D., Bertoja, E., & Piermarocchi, S. (1996). The effect of external eye irradiation on choroidal circulation. Ophthalmology, 103(10), 1651-1660.

The effect of external eye irradiation on choroidal circulation. / Midena, E.; Segato, T.; Valenti, M.; Angeli, C. D.; Bertoja, E.; Piermarocchi, S.

In: Ophthalmology, Vol. 103, No. 10, 1996, p. 1651-1660.

Research output: Contribution to journalArticle

Midena, E, Segato, T, Valenti, M, Angeli, CD, Bertoja, E & Piermarocchi, S 1996, 'The effect of external eye irradiation on choroidal circulation', Ophthalmology, vol. 103, no. 10, pp. 1651-1660.
Midena E, Segato T, Valenti M, Angeli CD, Bertoja E, Piermarocchi S. The effect of external eye irradiation on choroidal circulation. Ophthalmology. 1996;103(10):1651-1660.
Midena, E. ; Segato, T. ; Valenti, M. ; Angeli, C. D. ; Bertoja, E. ; Piermarocchi, S. / The effect of external eye irradiation on choroidal circulation. In: Ophthalmology. 1996 ; Vol. 103, No. 10. pp. 1651-1660.
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