TY - JOUR
T1 - The effect of flutamide on basal and ACTH-stimulated plasma levels of adrenal androgens in patients with advanced prostate cancer
AU - Balzano, S.
AU - Cappa, M.
AU - Migliari, R.
AU - Scarpa, R. M.
AU - Danielli, E.
AU - Campus, G.
AU - Pintus, C.
AU - Sica, V.
AU - Usai, E.
AU - Martino, E.
PY - 1988
Y1 - 1988
N2 - The effect of flutamide on basal and ACTH-stimulated plasma levels of adrenal androgens was investigated in 6 patients with untreated advanced prostate cancer, aged 52–75 yr. Flutamide was administered (250 mg three times daily) for 10 days; before and after treatment, a synthetic ACTH1 -24 stimulation test (250 µg im, with blood sampling immediately before and 60 min after the stimulus) was performed. Basal plasma 170H-pregnenolone (Δ5-170HP), 170H-progesterone (A4-170HP), androstenedione (A), dehydroepiandrosterone (DHEA) and its sulphate (DHEAS) were unchanged by flutamide treatment. In contrast, basal plasma testosterone (T) concentrations significantly increased (p <0.05). The response of Cortisol Δ 4-170HP, Δ 5-170HP, A and DHEA to ACTH, as well as the ACTH-stimulated Δ5-170HP/Δ4-170HP, Δ5-170HP/DHEA, Δ4-170HP/A and DHEA/A ratios, were unchanged by flutamide treatment. These findings indicate that: a) Short-term flutamide administration enhances testicular steroidogenesis, via augmented LH pulse frequency; b) Adrenal steroidogenesis seems to be not affected by the drug, since ACTH-stimulated plasma levels of adrenal androgens and precursors/products ratios were unchanged.
AB - The effect of flutamide on basal and ACTH-stimulated plasma levels of adrenal androgens was investigated in 6 patients with untreated advanced prostate cancer, aged 52–75 yr. Flutamide was administered (250 mg three times daily) for 10 days; before and after treatment, a synthetic ACTH1 -24 stimulation test (250 µg im, with blood sampling immediately before and 60 min after the stimulus) was performed. Basal plasma 170H-pregnenolone (Δ5-170HP), 170H-progesterone (A4-170HP), androstenedione (A), dehydroepiandrosterone (DHEA) and its sulphate (DHEAS) were unchanged by flutamide treatment. In contrast, basal plasma testosterone (T) concentrations significantly increased (p <0.05). The response of Cortisol Δ 4-170HP, Δ 5-170HP, A and DHEA to ACTH, as well as the ACTH-stimulated Δ5-170HP/Δ4-170HP, Δ5-170HP/DHEA, Δ4-170HP/A and DHEA/A ratios, were unchanged by flutamide treatment. These findings indicate that: a) Short-term flutamide administration enhances testicular steroidogenesis, via augmented LH pulse frequency; b) Adrenal steroidogenesis seems to be not affected by the drug, since ACTH-stimulated plasma levels of adrenal androgens and precursors/products ratios were unchanged.
KW - adrenal androgens
KW - antiandrogens
KW - Flutamide
KW - prostate cancer
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U2 - 10.1007/BF03350920
DO - 10.1007/BF03350920
M3 - Article
C2 - 2852689
AN - SCOPUS:0024241418
VL - 11
SP - 693
EP - 696
JO - Journal of Endocrinological Investigation
JF - Journal of Endocrinological Investigation
SN - 0391-4097
IS - 10
ER -