The effect of formulation and concentration of cholesteryl butyrate solid lipid nanospheres (SLN) on NIH-H460 cell proliferation

Elena Ugazio, Emilio Marengo, Cinzia Pellizzaro, Danila Coradini, Elena Peira, Maria Grazia Daidone, Maria Rosa Gasco

Research output: Contribution to journalArticlepeer-review

Abstract

Experimental factorial design was used to evaluate the influence of two factors involved in producing cholesteryl butyrate (chol-but) solid lipid nanospheres (SLN), microemulsion formulation and microemulsion/water ratio, on the effect of the SLN on the proliferation of NIH-H460, a non-small-cell lung carcinoma; six experimental settings were tested. The cells were treated with scalar concentrations of cholesteryl butyrate (from 0.008 to 1.000 mM) for each experimental condition; NIH-H460 cell growth was inhibited in all cases. The best experimental setting provided complete inhibition at 0.125 mM chol-but, while at the same concentration sodium butyrate provided only 38% inhibition.

Original languageEnglish
Pages (from-to)197-202
Number of pages6
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume52
Issue number2
DOIs
Publication statusPublished - 2001

Keywords

  • Cholesteryl butyrate
  • Colloidal systems
  • Factorial design
  • NIH-H460 cell proliferation
  • Solid lipid nanospheres

ASJC Scopus subject areas

  • Biotechnology
  • Pharmaceutical Science

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