The effect of fresh human serum on ofloxacin bactericidal activity

A. Fabbri, A. Tacchella, E. Ugolotti, M. L. Belli, T. Vittorino, A. Campelli

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Abstract

We have studied the possibility of an increase in ofloxacin bactericidal activity when it is combined with fresh human serum. The tested strains were 10 clinical isolates of Klebsiella pneumoniae. From among our strains 5 were susceptible to serum bactericidal activity and 5 were found to be resistant. We selected two serum concentrations (15 and 35%) to test against susceptible strains and two (55 and 75%) to test against resistant strains in combination with the minimum inhibitory concentration (MIC), 1/2 MIC and 1/4 MIC of ofloxacin. The results show a slight variability among the tested strains depending on microbiological characteristics of single strains, however, the serum + ofloxacin combination was advantageous. Only one exception was observed: a resistant strain that had an increased survival percentage against ofloxacin and serum in combination.

Original languageEnglish
Pages (from-to)164-166
Number of pages3
JournalJournal of Chemotherapy
Volume2
Issue number3
Publication statusPublished - 1990

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Ofloxacin
Microbial Sensitivity Tests
Serum
Klebsiella pneumoniae
Survival

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Microbiology (medical)

Cite this

Fabbri, A., Tacchella, A., Ugolotti, E., Belli, M. L., Vittorino, T., & Campelli, A. (1990). The effect of fresh human serum on ofloxacin bactericidal activity. Journal of Chemotherapy, 2(3), 164-166.

The effect of fresh human serum on ofloxacin bactericidal activity. / Fabbri, A.; Tacchella, A.; Ugolotti, E.; Belli, M. L.; Vittorino, T.; Campelli, A.

In: Journal of Chemotherapy, Vol. 2, No. 3, 1990, p. 164-166.

Research output: Contribution to journalArticle

Fabbri, A, Tacchella, A, Ugolotti, E, Belli, ML, Vittorino, T & Campelli, A 1990, 'The effect of fresh human serum on ofloxacin bactericidal activity', Journal of Chemotherapy, vol. 2, no. 3, pp. 164-166.
Fabbri, A. ; Tacchella, A. ; Ugolotti, E. ; Belli, M. L. ; Vittorino, T. ; Campelli, A. / The effect of fresh human serum on ofloxacin bactericidal activity. In: Journal of Chemotherapy. 1990 ; Vol. 2, No. 3. pp. 164-166.
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