The effect of fresh human serum on ofloxacin bactericidal activity

A. Fabbri, A. Tacchella, E. Ugolotti, M. L. Belli, T. Vittorino, A. Campelli

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We have studied the possibility of an increase in ofloxacin bactericidal activity when it is combined with fresh human serum. The tested strains were 10 clinical isolates of Klebsiella pneumoniae. From among our strains 5 were susceptible to serum bactericidal activity and 5 were found to be resistant. We selected two serum concentrations (15 and 35%) to test against susceptible strains and two (55 and 75%) to test against resistant strains in combination with the minimum inhibitory concentration (MIC), 1/2 MIC and 1/4 MIC of ofloxacin. The results show a slight variability among the tested strains depending on microbiological characteristics of single strains, however, the serum + ofloxacin combination was advantageous. Only one exception was observed: a resistant strain that had an increased survival percentage against ofloxacin and serum in combination.

Original languageEnglish
Pages (from-to)164-166
Number of pages3
JournalJournal of Chemotherapy
Issue number3
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Microbiology (medical)


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