The effect of frusemide, mexiletine, (+)-propranolol and three benzodiazepine drugs on interictal spike discharges in the electroencephalograms of epileptic patients

S. Ahmad, E. Perucca, A. Richens

Research output: Contribution to journalArticle

Abstract

The effects of single intravenous doses of diazepam, clonazepam, lorazepam, frusemide, mexiletine and (+)-propranolol on the frequency of electroencephalographic (EEG) interictal spike discharges were assessed in 3 double-blind placebo-controlled trials in 14 epileptic patients. Diazepam (5 mg) produced a significant mean decrease of spike discharges to about 1/3 of the control frequency. The effect developed rapidly and persisted for the duration of the study (up to 25 min after injection). A larger dose (10 mg) failed to produce a further reduction in the frequency of the spike discharges. Clonazepam (0.5 mg), frusemide (40 mg) and lorazepam (2 mg) appeared to be as effective as diazepam in reducing spike discharges, although the effect of the latter drug seemed to develop with some delay. Mexiletine (100 mg) and (+)-propranolol (50 mg) did not reduce paroxysmal EEG discharges, their effects being not significantly different from that of saline. EEG spike counting after intravenous administration of single test-doses appeared to be both a simple and promising technique for the rapid preliminary evaluation of the clinical efficacy of new antiepileptic drugs.

Original languageEnglish
Pages (from-to)683-688
Number of pages6
JournalBritish Journal of Clinical Pharmacology
Volume4
Issue number6
Publication statusPublished - 1977

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Mexiletine
Furosemide
Diazepam
Benzodiazepines
Propranolol
Clonazepam
Lorazepam
Electroencephalography
Pharmaceutical Preparations
Intravenous Administration
Anticonvulsants
Placebos
Injections

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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title = "The effect of frusemide, mexiletine, (+)-propranolol and three benzodiazepine drugs on interictal spike discharges in the electroencephalograms of epileptic patients",
abstract = "The effects of single intravenous doses of diazepam, clonazepam, lorazepam, frusemide, mexiletine and (+)-propranolol on the frequency of electroencephalographic (EEG) interictal spike discharges were assessed in 3 double-blind placebo-controlled trials in 14 epileptic patients. Diazepam (5 mg) produced a significant mean decrease of spike discharges to about 1/3 of the control frequency. The effect developed rapidly and persisted for the duration of the study (up to 25 min after injection). A larger dose (10 mg) failed to produce a further reduction in the frequency of the spike discharges. Clonazepam (0.5 mg), frusemide (40 mg) and lorazepam (2 mg) appeared to be as effective as diazepam in reducing spike discharges, although the effect of the latter drug seemed to develop with some delay. Mexiletine (100 mg) and (+)-propranolol (50 mg) did not reduce paroxysmal EEG discharges, their effects being not significantly different from that of saline. EEG spike counting after intravenous administration of single test-doses appeared to be both a simple and promising technique for the rapid preliminary evaluation of the clinical efficacy of new antiepileptic drugs.",
author = "S. Ahmad and E. Perucca and A. Richens",
year = "1977",
language = "English",
volume = "4",
pages = "683--688",
journal = "British Journal of Clinical Pharmacology",
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AU - Perucca, E.

AU - Richens, A.

PY - 1977

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N2 - The effects of single intravenous doses of diazepam, clonazepam, lorazepam, frusemide, mexiletine and (+)-propranolol on the frequency of electroencephalographic (EEG) interictal spike discharges were assessed in 3 double-blind placebo-controlled trials in 14 epileptic patients. Diazepam (5 mg) produced a significant mean decrease of spike discharges to about 1/3 of the control frequency. The effect developed rapidly and persisted for the duration of the study (up to 25 min after injection). A larger dose (10 mg) failed to produce a further reduction in the frequency of the spike discharges. Clonazepam (0.5 mg), frusemide (40 mg) and lorazepam (2 mg) appeared to be as effective as diazepam in reducing spike discharges, although the effect of the latter drug seemed to develop with some delay. Mexiletine (100 mg) and (+)-propranolol (50 mg) did not reduce paroxysmal EEG discharges, their effects being not significantly different from that of saline. EEG spike counting after intravenous administration of single test-doses appeared to be both a simple and promising technique for the rapid preliminary evaluation of the clinical efficacy of new antiepileptic drugs.

AB - The effects of single intravenous doses of diazepam, clonazepam, lorazepam, frusemide, mexiletine and (+)-propranolol on the frequency of electroencephalographic (EEG) interictal spike discharges were assessed in 3 double-blind placebo-controlled trials in 14 epileptic patients. Diazepam (5 mg) produced a significant mean decrease of spike discharges to about 1/3 of the control frequency. The effect developed rapidly and persisted for the duration of the study (up to 25 min after injection). A larger dose (10 mg) failed to produce a further reduction in the frequency of the spike discharges. Clonazepam (0.5 mg), frusemide (40 mg) and lorazepam (2 mg) appeared to be as effective as diazepam in reducing spike discharges, although the effect of the latter drug seemed to develop with some delay. Mexiletine (100 mg) and (+)-propranolol (50 mg) did not reduce paroxysmal EEG discharges, their effects being not significantly different from that of saline. EEG spike counting after intravenous administration of single test-doses appeared to be both a simple and promising technique for the rapid preliminary evaluation of the clinical efficacy of new antiepileptic drugs.

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