The effect of heparin on the interaction of factor VIII and human platelets in vitro

L. De Marco; F. Fabris; G. Molaro; A. Girolami

The effect of heparin on the interaction of factor VIII and human platelets in vitro

L. De Marco, F. Fabris, G. Molaro, A. Girolami

Centro di Riferimento Oncologico

Research output: Contribution to journal › Article › peer-review

Abstract

Heparin was found to inhibit the interaction between human factor VIII and platelets. This was noted in two different systems, namely, platelet aggregation induced by neuraminidase-treated human cryoprecipitate and platelet aggregration induced by ristocetin-human factor VIII complex. Heparin appeared to have an inhibitory effect on the above systems similar to that reported on bovine factor VIII-induced platelet aggregation.

Original language	English
Pages (from-to)	163-170
Number of pages	8
Journal	Haemostasis
Volume	6
Issue number	3
Publication status	Published - 1977

ASJC Scopus subject areas

Hematology

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title = "The effect of heparin on the interaction of factor VIII and human platelets in vitro",

abstract = "Heparin was found to inhibit the interaction between human factor VIII and platelets. This was noted in two different systems, namely, platelet aggregation induced by neuraminidase-treated human cryoprecipitate and platelet aggregration induced by ristocetin-human factor VIII complex. Heparin appeared to have an inhibitory effect on the above systems similar to that reported on bovine factor VIII-induced platelet aggregation.",

author = "{De Marco}, L. and F. Fabris and G. Molaro and A. Girolami",

year = "1977",

language = "English",

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AU - De Marco, L.

AU - Fabris, F.

AU - Molaro, G.

AU - Girolami, A.

PY - 1977

Y1 - 1977

N2 - Heparin was found to inhibit the interaction between human factor VIII and platelets. This was noted in two different systems, namely, platelet aggregation induced by neuraminidase-treated human cryoprecipitate and platelet aggregration induced by ristocetin-human factor VIII complex. Heparin appeared to have an inhibitory effect on the above systems similar to that reported on bovine factor VIII-induced platelet aggregation.

AB - Heparin was found to inhibit the interaction between human factor VIII and platelets. This was noted in two different systems, namely, platelet aggregation induced by neuraminidase-treated human cryoprecipitate and platelet aggregration induced by ristocetin-human factor VIII complex. Heparin appeared to have an inhibitory effect on the above systems similar to that reported on bovine factor VIII-induced platelet aggregation.

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