The effect of heparin on the interaction of factor VIII and human platelets in vitro

L. De Marco, F. Fabris, G. Molaro, A. Girolami

Research output: Contribution to journalArticlepeer-review

Abstract

Heparin was found to inhibit the interaction between human factor VIII and platelets. This was noted in two different systems, namely, platelet aggregation induced by neuraminidase-treated human cryoprecipitate and platelet aggregration induced by ristocetin-human factor VIII complex. Heparin appeared to have an inhibitory effect on the above systems similar to that reported on bovine factor VIII-induced platelet aggregation.

Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalHaemostasis
Volume6
Issue number3
Publication statusPublished - 1977

ASJC Scopus subject areas

  • Hematology

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