The effect of inflammation and its reduction on brain plasticity in multiple sclerosis: MRI evidence

Valentina Tomassini, Alessandro d'Ambrosio, Nikolaos Petsas, Richard G. Wise, Emilia Sbardella, Marek Allen, Francesca Tona, Fulvia Fanelli, Catherine Foster, Marco Carnì, Antonio Gallo, Patrizia Pantano, Carlo Pozzilli

Research output: Contribution to journalArticle

Abstract

Brain plasticity is the basis for systems-level functional reorganization that promotes recovery in multiple sclerosis (MS). As inflammation interferes with plasticity, its pharmacological modulation may restore plasticity by promoting desired patterns of functional reorganization. Here, we tested the hypothesis that brain plasticity probed by a visuomotor adaptation task is impaired with MS inflammation and that pharmacological reduction of inflammation facilitates its restoration. MS patients were assessed twice before (sessions 1 and 2) and once after (session 3) the beginning of Interferon beta (IFN beta), using behavioural and structural MRI measures. During each session, 2 functional MRI runs of a visuomotor task, separated by 25-minutes of task practice, were performed. Within-session between-run change in task-related functional signal was our imaging marker of plasticity. During session 1, patients were compared with healthy controls. Comparison of patients' sessions 2 and 3 tested the effect of reduced inflammation on our imaging marker of plasticity. The proportion of patients with gadolinium-enhancing lesions reduced significantly during IFN beta. In session 1, patients demonstrated a greater between-run difference in functional MRI activity of secondary visual areas and cerebellum than controls. This abnormally large practice-induced signal change in visual areas, and in functionally connected posterior parietal and motor cortices, was reduced in patients in session 3 compared with 2. Our results suggest that MS inflammation alters short-term plasticity underlying motor practice. Reduction of inflammation with IFN beta is associated with a restoration of this plasticity, suggesting that modulation of inflammation may enhance recovery-oriented strategies that rely on patients' brain plasticity. Hum Brain Mapp 37:2431–2445, 2016.

Original languageEnglish
Pages (from-to)2431-2445
Number of pages15
JournalHuman Brain Mapping
Volume37
Issue number7
DOIs
Publication statusPublished - Jul 1 2016

Keywords

  • brain plasticity
  • functional MRI
  • inflammation
  • interferon beta
  • multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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    Tomassini, V., d'Ambrosio, A., Petsas, N., Wise, R. G., Sbardella, E., Allen, M., Tona, F., Fanelli, F., Foster, C., Carnì, M., Gallo, A., Pantano, P., & Pozzilli, C. (2016). The effect of inflammation and its reduction on brain plasticity in multiple sclerosis: MRI evidence. Human Brain Mapping, 37(7), 2431-2445. https://doi.org/10.1002/hbm.23184