The effect of injections of fluorocitrate into the brains of rats

Paolo L. Morselli, Silvio Garattini, Franca Marcucci, Emilio Mussini, Wojciech Rewersky, Luigi Valzelli, Rudolph A. Peters

Research output: Contribution to journalArticlepeer-review

Abstract

Intracerebral injection of fluoroacetate and fluorocitrate were made in rats by manual and stereotaxic technique. Fluorocitrate was found to be at least 100 times more toxic than fluoroacetate under various experimental conditions. Fluorocitrate was more toxic when injected in the third cerebral ventricle, or in the nucleus reuniens thalami than when injected in the lobus frontalis. Gas chromatographic determination of fluoroacetate shows that this compound is rapidly removed as such from the brain. These results and their implications are discussed in relation to current views of the action of these compounds.

Original languageEnglish
Pages (from-to)195-202
Number of pages8
JournalBiochemical Pharmacology
Volume17
Issue number2
Publication statusPublished - Feb 1968

ASJC Scopus subject areas

  • Pharmacology

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