The effect of intraperitoneal insulin delivery on carbohydrate metabolism in type 1 (insulin-dependent) diabetic patients

L. D. Monti, P. M. Piatti, P. D. Home, C. Tomson, K. G M M Alberti

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Abstract

Patients with type 1 diabetes are usually given insulin subcutaneously, but this does not mimic the physiological route of pancreatic insulin release, which may be better achieved with intraperitoneal insulin. Five C-peptide negative type 1 diabetic patients were studied on two occasions, once with intravenous (IV) and once with intraperitoneal (IP) insulin. Normoglycaemia was maintained from 1700 h with variable insulin infusion, and glucose turnover and recycling assessed from 0600 to 0800 h. A 4-h hyperinsulinaemic (25 mU kg-1 h-1) euglycaemic clamp was then performed, with IP or IV insulin delivery. During the night similar insulin infusion rates were needed to achieve equal blood glucose concentrations. Glucose turnover was identical (IV: 2.4 ± 0.2 vs IP:2.3 ± 0.1 mg kg-1 min-1) (±SE) with glucose/carbon recycling 8.8 ± 4.7 and 12.8 ± 2.9% (NS). Blood lactate, pyruvate and alanine concentrations were significantly higher with IP than IV insulin (P <0.05). During the clamp, insulin concentration was 28 ± 3 mU/l with IV insulin and 15 ± 1 mU/l with IP insulin (P <0.05) and glucose requirement 2.0 ± 0.5 and 0.8 ± 0.3 mg kg-1 min-1, respectively (P <0.05). Glucose carbon recycling was higher with IP insulin (P <0.05). We conclude that: (1) in type 1 (insulin-dependent) diabetic patients hepatic glucose production could be normalized with both routes of insulin administration, and (2) at the same insulin infusion rate, the relative peripheral hypoinsulinaemia with IP route is sufficient to increase the rate of release of gluconeogenic precusors, or decrease their hepatic uptake.

Original languageEnglish
Pages (from-to)237-244
Number of pages8
JournalDiabetes Research and Clinical Practice
Volume15
Issue number3
DOIs
Publication statusPublished - 1992

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Keywords

  • Diabetes mellitus
  • Hepatic glucose output
  • Intermediary metabolites
  • Intraperitoneal insulin
  • Intravenous insulin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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