TY - JOUR
T1 - The effect of intravenous ferric carboxymaltose on red cell distribution width
T2 - A subanalysis of the FAIR-HF study
AU - Van Craenenbroeck, Emeline M.
AU - Conraads, Viviane M.
AU - Greenlaw, Nicola
AU - Gaudesius, Giedrius
AU - Mori, Claudio
AU - Ponikowski, Piotr
AU - Anker, Stefan D.
PY - 2013
Y1 - 2013
N2 - AimsRed cell distribution width (RDW), a measure of variability in red blood cell size, is a novel prognostic marker in chronic heart failure (CHF). Iron deficiency contributes to elevated RDW. In the FAIR-HF trial, i.v. ferric carboxymaltose (FCM) improved the 6 min walk test (6MWT) distance in iron-deficient CHF patients. We studied the effect of FCM on RDW and the relationship between RDW and 6MWT distance.Methods and resultsIn FAIR-HF, iron-deficient CHF patients were randomized to FCM or placebo in a 2:1 ratio. From the total cohort (n = 459), we included 415 patients in whom RDW values and 6MWT distance were available for baseline and at least one follow-up visit (after 4, 12, and 24 weeks). Baseline RDW was higher in anaemic (haemoglobin
AB - AimsRed cell distribution width (RDW), a measure of variability in red blood cell size, is a novel prognostic marker in chronic heart failure (CHF). Iron deficiency contributes to elevated RDW. In the FAIR-HF trial, i.v. ferric carboxymaltose (FCM) improved the 6 min walk test (6MWT) distance in iron-deficient CHF patients. We studied the effect of FCM on RDW and the relationship between RDW and 6MWT distance.Methods and resultsIn FAIR-HF, iron-deficient CHF patients were randomized to FCM or placebo in a 2:1 ratio. From the total cohort (n = 459), we included 415 patients in whom RDW values and 6MWT distance were available for baseline and at least one follow-up visit (after 4, 12, and 24 weeks). Baseline RDW was higher in anaemic (haemoglobin
KW - Chronic heart failure
KW - Exercise capacity
KW - Ferric carboxymaltose
KW - Iron deficiency
KW - Red cell distribution width
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U2 - 10.1093/eurjhf/hft068
DO - 10.1093/eurjhf/hft068
M3 - Article
C2 - 23639779
AN - SCOPUS:84879482070
VL - 15
SP - 756
EP - 762
JO - European Journal of Heart Failure
JF - European Journal of Heart Failure
SN - 1388-9842
IS - 7
ER -