The effect of intravenous thrombolytic therapy on post stroke depression and cognitive dysfunction: A 3-months follow up study

Michele Torrisi, Lilla Bonanno, Francesco Corallo, Caterina Formica, Roberto Giorgianni, Angela Marra, Placido Bramanti, Francesca Antonia Arcadi

Research output: Contribution to journalArticle

Abstract

Several studies have demonstrated the efficacy of intravenous thrombolytic therapy with recombinant plasminogen activator (rt-PA) on functional recovery at 3–18 months following the treatment. The objectives of this study were to investigate differences between thrombolytic or no thrombolytic treatment and if could be a relationship between patients who have underwent the thrombolytic treatment in terms of depressive symptoms and cognitive impairment. In this retrospective study, we evaluated 92 patients affected by ischemic stroke recruited from our rehabilitation center, coming from a Stroke Unit. All the eligible subjects were assessed at admission (T0) and two months later, at discharge, upon concluded the rehabilitation program (T1). The patients were divided into two groups: Thrombolysis Group (n.40 subjects) and no Thrombolysis Group (n.52 subjects). Cognitive functions were evaluated with the Montreal Overall Cognitive Assessment. Functional status were evaluated with the Barthel Index and the Functional Independent Misure. We administered Beck Depression Inventory-II to verify the presence of a depressive state. We found that at three months after stroke, the prevalence of depressive symptoms and cognitive improvement, among patient who had undergone thrombolytic treatment, and who had not, was not different. Conversely, we found an improvement of depressive symptoms in each group.

Original languageEnglish
Pages (from-to)1-4
JournalApplied Neuropsychology:Adult
DOIs
Publication statusAccepted/In press - Oct 6 2020

Keywords

  • Cognitive dysfunction
  • depression
  • rehabilitation
  • stroke
  • thrombolysis

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Developmental and Educational Psychology

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