The effect of ionophore on platelet aggregation in von willebrand’s disease and in congenital afibrinogenemia. A comparison with ristocetin

Antonio Girolami, Fabrizio Fabris, Luigino De Marco, Renata Peruffo

Research output: Contribution to journalArticlepeer-review

Abstract

Platelet aggregation in citrated and heparinized plasma by ionophore A 23187 and Ristocetin was studied in normal subjects and in patients with von Willebrand’s disease and congenital afibrinogenemia. Aggregation by ionophore was normal in all groups both in citrated and heparinized plasma. Aggregation by Ristocetin in citrated plasma was normal in congenital afibrinogenemia, in normal subjects and in types II and III of von Willebrand’s disease. It was absent in classical von Willebrand’s disease, type I. In heparinized plasma it was absent in all groups, except in some patients with von Willebrand’s disease, type III. It is concluded that ionophore A 23187 behaves in a different way than Ristocetin and has no diagnostic implications.

Original languageEnglish
Pages (from-to)151-159
Number of pages9
JournalActa Haematologica
Volume56
Issue number3
DOIs
Publication statusPublished - 1976

Keywords

  • Afibrinogenemia
  • Blood coagulation
  • Ionophores
  • Platelet aggregation
  • Ristocetin
  • Von Willebrand’s disease

ASJC Scopus subject areas

  • Hematology

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