The effect of ischemia and reperfusion on microvascular function

A human in vivo comparative study with conduit arteries

Tommaso Gori, Giuseppe Di Stolfo, Silvia Sicuro, Saverio Dragoni, John D. Parker, Sandro Forconi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Although microvascular dysfunction is of critical importance in the pathophysiology of myocardial ischemic syndromes, no study has investigated whether there are differences in the sensitivity to ischemia and reperfusion injury between microvessels and conduit arteries. Ten healthy young nonsmoking male volunteers (age range 24-5) were enrolled. Parameters measured included radial (conduit) artery (endothelium-dependent) flow-mediated dilation, microvascular cutaneous reactive hyperemia (using laser Doppler) and acetylcholine-induced microvascular vasodilation (laser Doppler iontophoresis). Data were acquired before and after ischemic injury (15 minutes of ischemia of the brachial artery followed by 15 minutes reperfusion) and analyzed in a randomized, blinded fashion. Conduit artery FMD was significantly blunted after ischemia (before: 7.5 ± 1.1%; after: 2.9 ± 1.0%, P <0.05). Conversely, ischemia had no effect on microvascular reactive hyperemia (P = ns) and acetylcholine-induced vasodilation (P = ns). Using a human in vivo model, we demonstrate that microvessels are more resistant to ischemic injury as compared to conduit arteries.

Original languageEnglish
Pages (from-to)169-173
Number of pages5
JournalClinical Hemorheology and Microcirculation
Volume35
Issue number1-2
Publication statusPublished - 2006

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Reperfusion
Ischemia
Arteries
Hyperemia
Microvessels
Vasodilation
Acetylcholine
Lasers
Iontophoresis
Radial Artery
Brachial Artery
Wounds and Injuries
Reperfusion Injury
Endothelium
Dilatation
Volunteers
Skin

ASJC Scopus subject areas

  • Hematology
  • Physiology

Cite this

The effect of ischemia and reperfusion on microvascular function : A human in vivo comparative study with conduit arteries. / Gori, Tommaso; Di Stolfo, Giuseppe; Sicuro, Silvia; Dragoni, Saverio; Parker, John D.; Forconi, Sandro.

In: Clinical Hemorheology and Microcirculation, Vol. 35, No. 1-2, 2006, p. 169-173.

Research output: Contribution to journalArticle

Gori, Tommaso ; Di Stolfo, Giuseppe ; Sicuro, Silvia ; Dragoni, Saverio ; Parker, John D. ; Forconi, Sandro. / The effect of ischemia and reperfusion on microvascular function : A human in vivo comparative study with conduit arteries. In: Clinical Hemorheology and Microcirculation. 2006 ; Vol. 35, No. 1-2. pp. 169-173.
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