The effect of ischemia and reperfusion on microvascular function: A human in vivo comparative study with conduit arteries

Tommaso Gori, Giuseppe Di Stolfo, Silvia Sicuro, Saverio Dragoni, John D. Parker, Sandro Forconi

Research output: Contribution to journalArticle

Abstract

Although microvascular dysfunction is of critical importance in the pathophysiology of myocardial ischemic syndromes, no study has investigated whether there are differences in the sensitivity to ischemia and reperfusion injury between microvessels and conduit arteries. Ten healthy young nonsmoking male volunteers (age range 24-5) were enrolled. Parameters measured included radial (conduit) artery (endothelium-dependent) flow-mediated dilation, microvascular cutaneous reactive hyperemia (using laser Doppler) and acetylcholine-induced microvascular vasodilation (laser Doppler iontophoresis). Data were acquired before and after ischemic injury (15 minutes of ischemia of the brachial artery followed by 15 minutes reperfusion) and analyzed in a randomized, blinded fashion. Conduit artery FMD was significantly blunted after ischemia (before: 7.5 ± 1.1%; after: 2.9 ± 1.0%, P <0.05). Conversely, ischemia had no effect on microvascular reactive hyperemia (P = ns) and acetylcholine-induced vasodilation (P = ns). Using a human in vivo model, we demonstrate that microvessels are more resistant to ischemic injury as compared to conduit arteries.

Original languageEnglish
Pages (from-to)169-173
Number of pages5
JournalClinical Hemorheology and Microcirculation
Volume35
Issue number1-2
Publication statusPublished - 2006

ASJC Scopus subject areas

  • Hematology
  • Physiology

Fingerprint Dive into the research topics of 'The effect of ischemia and reperfusion on microvascular function: A human in vivo comparative study with conduit arteries'. Together they form a unique fingerprint.

Cite this