The effect of L-Dopa administration on pursuit ocular movements in suspected Parkinson's disease

Silvia Marino, Pietro Lanzafame, Edoardo Sessa, Alessia Bramanti, Placido Bramanti

Research output: Contribution to journalArticlepeer-review

Abstract

The objective of this study is to evaluate pursuit ocular movements (POM) by using a vision-based non-intrusive eye tracker, in patients with suspected Parkinson's disease (PD), before and after L-Dopa administration. We studied ten patients with suspected diagnosis of idiopathic PD. We compared POM values to those of a group of normal controls (NC), and evaluated them before and after L-Dopa administration. Unified Parkinson's Disease Rating Scale (UPDRS) motor subscores improved significantly (p = 0.001). At baseline, values of POM were lower in suspected PD patients than in NC (p = 0.01). One hour after L-Dopa administration, POM values correlated with UPDRS motor subscore (p = 0.01). We used a recent method, a new vision-based non-intrusive eye tracker, previously described, which can be proposed as a possible tool for supporting the diagnosis of PD in association with levodopa test, as an add-on to the UPDRS score.

Original languageEnglish
Pages (from-to)381-385
Number of pages5
JournalNeurological Sciences
Volume31
Issue number3
DOIs
Publication statusPublished - Jun 2010

Keywords

  • L-Dopa
  • Parkinson disease
  • Pursuit ocular movements
  • Vision-based eye-tracking system

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology
  • Medicine(all)

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