The effect of liver transplantation on fatigue in patients with primary biliary cirrhosis: A prospective study

Marco Carbone, Sally Bufton, Andrea Monaco, Laura Griffiths, David E. Jones, James M. Neuberger

Research output: Contribution to journalArticlepeer-review

Abstract

Background & Aims The role of liver transplantation (LT) for the relief of fatigue in patients with primary biliary cirrhosis (PBC) is unclear, and while many centers exclude fatigue as an indication for transplantation, there have been no studies to prospectively evaluate the impact of LT on fatigue. We aimed at assessing the severity of fatigue in LT candidates with PBC and the impact of LT on fatigue. Methods In a prospective, longitudinal study, we used the PBC-40 questionnaire in 49 adult patients with PBC at listing and at 6, 12, and 24 months after LT and in two sex- and age-matched cohorts of community controls and non-transplanted PBC patients. Correlation analysis was used to assess the relationship between liver function and fatigue. ANOVA was used to compare the variation of fatigue score before and after LT. Results There was no correlation between MELD and fatigue before LT (r2 = 0.01). Overall, the fatigue score after LT was substantially lower than before LT, falling from 40.7 ± 11.4 pre-transplant to 27.7 ± 9.5, 28.7 ± 10.1, 26.2 ± 10.1 (p

Original languageEnglish
Pages (from-to)490-494
Number of pages5
JournalJournal of Hepatology
Volume59
Issue number3
DOIs
Publication statusPublished - Sep 2013

Keywords

  • Fatigue
  • Liver transplantation
  • PBC-40
  • Primary biliary cirrhosis
  • Quality of life

ASJC Scopus subject areas

  • Hepatology

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