The effect of local production of cytokines in the pathogenesis of insulin-dependent diabetes mellitus

Marika Falcone, Nora Sarvetnick

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease mediated by self-reactive T cells that induce inflammation and destruction of pancreatic islet β cells. A widely held belief is that T helper lymphocytes carrying a type 1 inflammatory phenotype are the major players in generating IDDM. However, recent evidence shows that cytokines belonging to the Th2 pathway can also induce autoimmune diabetes. The expression of cytokines directly within the pancreatic islets of transgenic mice helped to characterize the modulatory effects that Th1 or Th2 cytokines play on T cell- mediated autoimmune responses and diabetogenesis. This review describes the new information that these transgenic models have provided in understanding the exceedingly complex cytokine network and its role in the pathogenesis of IDDM.

Original languageEnglish
Pages (from-to)2-9
Number of pages8
JournalClinical Immunology
Volume90
Issue number1
DOIs
Publication statusPublished - Jan 1999

Fingerprint

Type 1 Diabetes Mellitus
Islets of Langerhans
Cytokines
T-Lymphocytes
Helper-Inducer T-Lymphocytes
Autoimmunity
Transgenic Mice
Autoimmune Diseases
Inflammation
Phenotype

Keywords

  • Cytokines
  • Insulin-dependent diabetes mellitus
  • Transgenic models

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

The effect of local production of cytokines in the pathogenesis of insulin-dependent diabetes mellitus. / Falcone, Marika; Sarvetnick, Nora.

In: Clinical Immunology, Vol. 90, No. 1, 01.1999, p. 2-9.

Research output: Contribution to journalArticle

@article{ac10c745884d4a8594d58df56fb3a25d,
title = "The effect of local production of cytokines in the pathogenesis of insulin-dependent diabetes mellitus",
abstract = "Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease mediated by self-reactive T cells that induce inflammation and destruction of pancreatic islet β cells. A widely held belief is that T helper lymphocytes carrying a type 1 inflammatory phenotype are the major players in generating IDDM. However, recent evidence shows that cytokines belonging to the Th2 pathway can also induce autoimmune diabetes. The expression of cytokines directly within the pancreatic islets of transgenic mice helped to characterize the modulatory effects that Th1 or Th2 cytokines play on T cell- mediated autoimmune responses and diabetogenesis. This review describes the new information that these transgenic models have provided in understanding the exceedingly complex cytokine network and its role in the pathogenesis of IDDM.",
keywords = "Cytokines, Insulin-dependent diabetes mellitus, Transgenic models",
author = "Marika Falcone and Nora Sarvetnick",
year = "1999",
month = "1",
doi = "10.1006/clim.1998.4619",
language = "English",
volume = "90",
pages = "2--9",
journal = "Clinical Immunology",
issn = "1521-6616",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - The effect of local production of cytokines in the pathogenesis of insulin-dependent diabetes mellitus

AU - Falcone, Marika

AU - Sarvetnick, Nora

PY - 1999/1

Y1 - 1999/1

N2 - Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease mediated by self-reactive T cells that induce inflammation and destruction of pancreatic islet β cells. A widely held belief is that T helper lymphocytes carrying a type 1 inflammatory phenotype are the major players in generating IDDM. However, recent evidence shows that cytokines belonging to the Th2 pathway can also induce autoimmune diabetes. The expression of cytokines directly within the pancreatic islets of transgenic mice helped to characterize the modulatory effects that Th1 or Th2 cytokines play on T cell- mediated autoimmune responses and diabetogenesis. This review describes the new information that these transgenic models have provided in understanding the exceedingly complex cytokine network and its role in the pathogenesis of IDDM.

AB - Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease mediated by self-reactive T cells that induce inflammation and destruction of pancreatic islet β cells. A widely held belief is that T helper lymphocytes carrying a type 1 inflammatory phenotype are the major players in generating IDDM. However, recent evidence shows that cytokines belonging to the Th2 pathway can also induce autoimmune diabetes. The expression of cytokines directly within the pancreatic islets of transgenic mice helped to characterize the modulatory effects that Th1 or Th2 cytokines play on T cell- mediated autoimmune responses and diabetogenesis. This review describes the new information that these transgenic models have provided in understanding the exceedingly complex cytokine network and its role in the pathogenesis of IDDM.

KW - Cytokines

KW - Insulin-dependent diabetes mellitus

KW - Transgenic models

UR - http://www.scopus.com/inward/record.url?scp=0032961365&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032961365&partnerID=8YFLogxK

U2 - 10.1006/clim.1998.4619

DO - 10.1006/clim.1998.4619

M3 - Article

VL - 90

SP - 2

EP - 9

JO - Clinical Immunology

JF - Clinical Immunology

SN - 1521-6616

IS - 1

ER -