Abstract
OBJECTIVES: To determine whether nightly administration of melatonin, magnesium, and zinc improves primary insomnia in long-term care facility residents. DESIGN: Double-blind, placebo-controlled clinical trial. SETTING: One long-term care facility in Pavia, Italy. PARTICIPANTS: Forty-three participants with primary insomnia (22 in the supplemented group, 21 in the placebo group) aged 78.3±3.9. INTERVENTION: Participants took a food supplement (5 mg melatonin, 225 mg magnesium, and 11.25 mg zinc, mixed with 100 g of pear pulp) or placebo (100 g pear pulp) every day for 8 weeks, 1 hour before bedtime. MEASUREMENTS: The primary goal was to evaluate sleep quality using the Pittsburgh Sleep Quality Index. The Epworth Sleepiness Scale, the Leeds Sleep Evaluation Questionnaire (LSEQ), the Short Insomnia Questionnaire (SDQ), and a validated quality-of-life instrument (Medical Outcomes Study 36-item Short Form Survey (SF-36)) were administered as secondary end points. Total sleep time was evaluated using a wearable armband-shaped sensor. All measures were performed at baseline and after 60 days. RESULTS: The food supplement resulted in considerably better overall PSQI scores than placebo (difference between groups in change from baseline PSQI score=6.8; 95% confidence interval=5.4-8.3, P
| Original language | English |
|---|---|
| Pages (from-to) | 82-90 |
| Number of pages | 9 |
| Journal | Journal of the American Geriatrics Society |
| Volume | 59 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2011 |
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Keywords
- dietary supplement
- elderly
- insomnia
- magnesium
- melatonin
- zinc
ASJC Scopus subject areas
- Geriatrics and Gerontology
Cite this
The effect of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in italy : A double-blind, placebo-controlled clinical trial. / Rondanelli, Mariangela; Opizzi, Annalisa; Monteferrario, Francesca; Antoniello, Neldo; Manni, Raffaele; Klersy, Catherine.
In: Journal of the American Geriatrics Society, Vol. 59, No. 1, 01.2011, p. 82-90.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in italy
T2 - A double-blind, placebo-controlled clinical trial
AU - Rondanelli, Mariangela
AU - Opizzi, Annalisa
AU - Monteferrario, Francesca
AU - Antoniello, Neldo
AU - Manni, Raffaele
AU - Klersy, Catherine
PY - 2011/1
Y1 - 2011/1
N2 - OBJECTIVES: To determine whether nightly administration of melatonin, magnesium, and zinc improves primary insomnia in long-term care facility residents. DESIGN: Double-blind, placebo-controlled clinical trial. SETTING: One long-term care facility in Pavia, Italy. PARTICIPANTS: Forty-three participants with primary insomnia (22 in the supplemented group, 21 in the placebo group) aged 78.3±3.9. INTERVENTION: Participants took a food supplement (5 mg melatonin, 225 mg magnesium, and 11.25 mg zinc, mixed with 100 g of pear pulp) or placebo (100 g pear pulp) every day for 8 weeks, 1 hour before bedtime. MEASUREMENTS: The primary goal was to evaluate sleep quality using the Pittsburgh Sleep Quality Index. The Epworth Sleepiness Scale, the Leeds Sleep Evaluation Questionnaire (LSEQ), the Short Insomnia Questionnaire (SDQ), and a validated quality-of-life instrument (Medical Outcomes Study 36-item Short Form Survey (SF-36)) were administered as secondary end points. Total sleep time was evaluated using a wearable armband-shaped sensor. All measures were performed at baseline and after 60 days. RESULTS: The food supplement resulted in considerably better overall PSQI scores than placebo (difference between groups in change from baseline PSQI score=6.8; 95% confidence interval=5.4-8.3, P
AB - OBJECTIVES: To determine whether nightly administration of melatonin, magnesium, and zinc improves primary insomnia in long-term care facility residents. DESIGN: Double-blind, placebo-controlled clinical trial. SETTING: One long-term care facility in Pavia, Italy. PARTICIPANTS: Forty-three participants with primary insomnia (22 in the supplemented group, 21 in the placebo group) aged 78.3±3.9. INTERVENTION: Participants took a food supplement (5 mg melatonin, 225 mg magnesium, and 11.25 mg zinc, mixed with 100 g of pear pulp) or placebo (100 g pear pulp) every day for 8 weeks, 1 hour before bedtime. MEASUREMENTS: The primary goal was to evaluate sleep quality using the Pittsburgh Sleep Quality Index. The Epworth Sleepiness Scale, the Leeds Sleep Evaluation Questionnaire (LSEQ), the Short Insomnia Questionnaire (SDQ), and a validated quality-of-life instrument (Medical Outcomes Study 36-item Short Form Survey (SF-36)) were administered as secondary end points. Total sleep time was evaluated using a wearable armband-shaped sensor. All measures were performed at baseline and after 60 days. RESULTS: The food supplement resulted in considerably better overall PSQI scores than placebo (difference between groups in change from baseline PSQI score=6.8; 95% confidence interval=5.4-8.3, P
KW - dietary supplement
KW - elderly
KW - insomnia
KW - magnesium
KW - melatonin
KW - zinc
UR - http://www.scopus.com/inward/record.url?scp=78651399199&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78651399199&partnerID=8YFLogxK
U2 - 10.1111/j.1532-5415.2010.03232.x
DO - 10.1111/j.1532-5415.2010.03232.x
M3 - Article
C2 - 21226679
AN - SCOPUS:78651399199
VL - 59
SP - 82
EP - 90
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
SN - 0002-8614
IS - 1
ER -