TY - JOUR
T1 - The Effect of Natural Antioxidants in the Development of Metabolic Syndrome
T2 - Focus on Bergamot Polyphenolic Fraction
AU - Carresi, Cristina
AU - Gliozzi, Micaela
AU - Musolino, Vincenzo
AU - Scicchitano, Miriam
AU - Scarano, Federica
AU - Bosco, Francesca
AU - Nucera, Saverio
AU - Maiuolo, Jessica
AU - Macrì, Roberta
AU - Ruga, Stefano
AU - Oppedisano, Francesca
AU - Zito, Maria Caterina
AU - Guarnieri, Lorenza
AU - Mollace, Rocco
AU - Tavernese, Annamaria
AU - Palma, Ernesto
AU - Bombardelli, Ezio
AU - Fini, Massimo
AU - Mollace, Vincenzo
N1 - Funding Information:
The work has been supported by the public resources from the Italian Ministry of Research. This work has been supported by PON-MIUR 03PE000_78_1 and PONMIUR 03PE000_78_2.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/5
Y1 - 2020/5
N2 - Metabolic syndrome (MetS) represents a set of clinical findings that include visceral adiposity, insulin-resistance, high triglycerides (TG), low high-density lipoprotein cholesterol (HDL-C) levels and hypertension, which is linked to an increased risk of developing type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease (ASCVD). The pathogenesis of MetS involves both genetic and acquired factors triggering oxidative stress, cellular dysfunction and systemic inflammation process mainly responsible for the pathophysiological mechanism. In recent years, MetS has gained importance due to the exponential increase in obesity worldwide. However, at present, it remains underdiagnosed and undertreated. The present review will summarize the pathogenesis of MetS and the existing pharmacological therapies currently used and focus attention on the beneficial effects of natural compounds to reduce the risk and progression of MetS. In this regard, emerging evidence suggests a potential protective role of bergamot extracts, in particular bergamot flavonoids, in the management of different features of MetS, due to their pleiotropic anti-oxidative, anti-inflammatory and lipid-lowering effects.
AB - Metabolic syndrome (MetS) represents a set of clinical findings that include visceral adiposity, insulin-resistance, high triglycerides (TG), low high-density lipoprotein cholesterol (HDL-C) levels and hypertension, which is linked to an increased risk of developing type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease (ASCVD). The pathogenesis of MetS involves both genetic and acquired factors triggering oxidative stress, cellular dysfunction and systemic inflammation process mainly responsible for the pathophysiological mechanism. In recent years, MetS has gained importance due to the exponential increase in obesity worldwide. However, at present, it remains underdiagnosed and undertreated. The present review will summarize the pathogenesis of MetS and the existing pharmacological therapies currently used and focus attention on the beneficial effects of natural compounds to reduce the risk and progression of MetS. In this regard, emerging evidence suggests a potential protective role of bergamot extracts, in particular bergamot flavonoids, in the management of different features of MetS, due to their pleiotropic anti-oxidative, anti-inflammatory and lipid-lowering effects.
KW - Bergamot
KW - Metabolic syndrome
KW - Natural antioxidant
KW - Plant extracts
KW - Polyphenols
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U2 - 10.3390/nu12051504
DO - 10.3390/nu12051504
M3 - Review article
C2 - 32455840
AN - SCOPUS:85085307684
VL - 12
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 5
M1 - 1504
ER -